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Umbelliferone

Name: Umbelliferone
Brand: TargetMol
SKU: T1693
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1693Cas No. 93-35-6

Alias Skimmetine, NSC 19790, Hydrangine, Hydrangin, 7-Hydroxycoumarin

Umbelliferone (7-Hydroxycoumarin) is found in anise. Umbelliferone occurs widely in plants including Angelica species Phytoalexin of infected sweet potat. It has been reported to have antioxidant properties.

Umbelliferone

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Purity: 99.64%

Catalog No. T1693Alias Skimmetine, NSC 19790, Hydrangine, Hydrangin, 7-HydroxycoumarinCas No. 93-35-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$31	-	In Stock
2 g	$37	-	In Stock
5 g	$48	-	In Stock
10 g	$58	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Umbelliferone AI Summary

Umbelliferone is a multifaceted chemical entity with a diverse range of bioactivities and pharmacological properties. It exhibits inhibitory activity against several enzymatic targets including 5-alpha-reductase type 1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), xanthine oxidase, acetylcholinesterase, soybean lipoxygenase, aldose reductase, sorbitol dehydrogenase, tyrosinase, and various carbonic anhydrase isoforms (specifically CA1, CA9, CA12). Notably, it demonstrates potent inhibitory effects on human carbonic anhydrase 9 with a Ki value of 24.9 nM. The compound also shows significant antioxidant properties, evidenced by its ability to induce NAD(P)H quinone reductase activity and DPPH radical scavenging activity, alongside its potential to inhibit lipid peroxidation and superoxide radical production. Moreover, it has demonstrated cytoprotective, anti-inflammatory, antimutagenic, antimycobacterial, antiproliferative, and antiviral activities. For instance, Umbelliferone shows antiviral activity against SARS-CoV-2 by inhibiting 3CL-Pro protease and virus-induced cytotoxicity in VERO-6 cells. In terms of cytotoxicity, Umbelliferone affects several human cell lines, including V-79, Lu1, LNCAP, MCF7, HUVEC, P388, MT4, HCT116, HT-29, OE21, LoVo, and others, with varying degrees of potency. It also displays anticancer activity against multiple tumor cell lines, suggesting its potential in oncology. Additionally, the compound has shown antimicrobial activity, particularly against Mycobacterium tuberculosis and Staphylococcus aureus. Pharmacokinetically, Umbelliferone exhibits rapid metabolism in liver S9 fractions of various species, indicating a relatively short half-life and high intrinsic clearance rates. This may impact its bioavailability and systemic duration. Nevertheless, it maintains stability in human liver microsomes, suggesting suitability for further development. Umbelliferone also possesses other notable activities, such as antiasthmatic, antifeedant, and gastric cytoprotective effects, and a range of enzyme inhibition properties that can be leveraged for therapeutic interventions in diseases like Alzheimer’s, cancer, and infections. It demonstrates modulation of processes involving Menin-MLL interactions, HSD17B4, Caspase enzymes, TDP1, Cruzain, and several others, further underscoring its extensive bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Umbelliferone (7-Hydroxycoumarin) is found in anise. Umbelliferone occurs widely in plants including Angelica species Phytoalexin of infected sweet potat. It has been reported to have antioxidant properties.
Synonyms	Skimmetine, NSC 19790, Hydrangine, Hydrangin, 7-Hydroxycoumarin

Chemical Properties

Molecular Weight	162.14
Formula	C₉H₆O₃
Cas No.	93-35-6
Smiles	OC=1C=C2C(C=CC(=O)O2)=CC1
Relative Density.	1.2599 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1541.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1675 mL	30.8375 mL	61.6751 mL	308.3755 mL
5 mM	1.2335 mL	6.1675 mL	12.3350 mL	61.6751 mL
10 mM	0.6168 mL	3.0838 mL	6.1675 mL	30.8375 mL
20 mM	0.3084 mL	1.5419 mL	3.0838 mL	15.4188 mL
50 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
100 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc