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Anti-R-Spondin 2/RSPO2 Polyclonal Antibody (Synonyms: R-spondin 2, CRISTIN2)

Catalog No. TMAB-01637 Copy Product Info
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Anti-R-Spondin 2/RSPO2 Polyclonal Antibody is a Rabbit antibody targeting R-Spondin 2/RSPO2. Anti-R-Spondin 2/RSPO2 Polyclonal Antibody can be used in WB.

Anti-R-Spondin 2/RSPO2 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-01637
Synonyms R-spondin 2, CRISTIN2

Anti-R-Spondin 2/RSPO2 Polyclonal Antibody is a Rabbit antibody targeting R-Spondin 2/RSPO2. Anti-R-Spondin 2/RSPO2 Polyclonal Antibody can be used in WB.

Anti-R-Spondin 2/RSPO2 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5297-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-R-Spondin 2/RSPO2 Polyclonal Antibody is a Rabbit antibody targeting R-Spondin 2/RSPO2. Anti-R-Spondin 2/RSPO2 Polyclonal Antibody can be used in WB.
SynonymsR-spondin 2, CRISTIN2
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human,Dog,Pig,Cow)
Verified Activity
Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Large intestine tissue lysates
Lane 3: Mouse Placenta tissue lysates
Lane 4: Mouse Liver tissue lysates
Lane 5: Mouse Lung tissue lysates
Lane 6: Rat Cerebrum tissue lysates
Lane 7: Rat Large intestine tissue lysates
Lane 8: Rat Placenta tissue lysates
Lane 9: Rat Liver tissue lysates
Lane 10: Rat Lung tissue lysates
Primary: Anti-RSPO2 (TMAB-01637) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 26 kDa
Observed band size: 28 kDa
verifiedActivity
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundR-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human RSPO2
Antigen Species
Human
Gene Name
RSPO2
Gene ID
340419
Protein Name
R-spondin-2
Uniprot ID
Q6UXX9
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.
Chemical Properties
Molecular WeightTheoretical: 26 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Keywords

CRISTIN-2CRISTIN 2
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