Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

(E/Z)-E64FC26

Name: (E/Z)-E64FC26
Brand: TargetMol
SKU: T39812
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T39812Cas No. 2285446-67-3

(E/Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E/Z)-E64FC26 can be used for myeloma research.

(E/Z)-E64FC26

Copy Product Info

😃Good

Purity: 98.23%

Catalog No. T39812Cas No. 2285446-67-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$149	7-10 days	7-10 days
2 mg	Preferential	-	In Stock
5 mg	Preferential	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.23%

Appearance:Solid

Color:Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description	(E/Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E/Z)-E64FC26 can be used for myeloma research.
Targets&IC50	PDIA4:25.9 μM, PDIA6:25.4 μM, PDIA3:20.9 μM, TXNDC5:16.3 μM, PDIA1:1.9 μM
In vitro	(E/Z)-E64FC26 is an effective broad-spectrum inhibitor of the protein disulfide isomerase (PDI) family, with half-maximal inhibitory concentrations (IC50) of 1.9, 20.9, 25.9, 16.3, and 25.4 μM for PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Additionally, (E/Z)-E64FC26 demonstrates anti-myeloma activity. [1][2]

Chemical Properties

Molecular Weight	340.38
Formula	C₁₉H₂₃F₃O₂
Cas No.	2285446-67-3
Smiles	FC(F)(F)C1=CC(=CCCCCCCCC)C=2C=C(O)C(O)=CC21

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (235.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9379 mL	14.6895 mL	29.3789 mL	146.8946 mL
5 mM	0.5876 mL	2.9379 mL	5.8758 mL	29.3789 mL
10 mM	0.2938 mL	1.4689 mL	2.9379 mL	14.6895 mL
20 mM	0.1469 mL	0.7345 mL	1.4689 mL	7.3447 mL
50 mM	0.0588 mL	0.2938 mL	0.5876 mL	2.9379 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4689 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc