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Deferasirox

Name: Deferasirox
Brand: TargetMol
SKU: T1457
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1457Cas No. 201530-41-8

Alias ICL 670, CGP-72670

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

Deferasirox

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Purity: 99.4%

Catalog No. T1457Alias ICL 670, CGP-72670Cas No. 201530-41-8

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$43	In Stock	In Stock
10 mg	$61	In Stock	In Stock
25 mg	$79	In Stock	In Stock
50 mg	$119	In Stock	In Stock
100 mg	$173	In Stock	In Stock
500 mg	$429	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.4%

Color:White

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COA

Product Introduction

Bioactivity

Description	Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.
In vitro	Orally administered Deferasirox in rats achieves an absorption rate of at least 75% with a bioavailability of 26%. Monotherapy with Deferasirox modestly increases the survival time in IPA mice. When administered, either intravenously or orally, Deferasirox mainly circulates in the blood as its unaltered form and its iron complex, with a 99.2% binding rate to plasma proteins. Deferasirox significantly enhances survival rates and reduces tissue fungal burden in mice with diabetic ketoacidosis or neutropenia suffering from mucormycosis, showing effects comparable to those of liposomal Amphotericin B. Additionally, Deferasirox bolsters the host inflammatory response against mucormycosis. The combined use of Deferasirox and liposomal Amphotericin B synergistically improves survival rates and decreases fungal load in tissues affected by mucormycosis.
In vivo	Deferasirox exhibits antifungal activity against Aspergillus with MIC (Minimum Inhibitory Concentration) and MFC (Minimum Fungicidal Concentration) values of 25 and 50 mg/L, respectively. It effectively chelates iron ions from Rhizopus species, showing antiviral activity in vitro against 28 out of 29 Mucorales clinical isolates at concentrations much lower than those achievable in clinical serum levels. Deferasirox significantly inhibits the activity of NF-κB by chelating its active subunit p65 in an inactive form within the cytoplasm in 28 out of 40 peripheral blood samples. Additionally, it inhibits three human myeloid cell lines (K562, U937, and HL60) with IC50 values ranging from 17 to 50 mM.
Cell Research	Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50 μM of deferasirox for 24 or 48 h, and proliferation is determined by an MTT assay[2].
Synonyms	ICL 670, CGP-72670

Chemical Properties

Molecular Weight	373.36
Formula	C₂₁H₁₅N₃O₄
Cas No.	201530-41-8
Smiles	OC1=C(C=2N(N=C(N2)C3=C(O)C=CC=C3)C4=CC=C(C(O)=O)C=C4)C=CC=C1
Relative Density.	1.472g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 240 mg/mL (642.81 mM), Sonication is recommended.

Ethanol: 2 mg/mL (5.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6784 mL	13.3919 mL	26.7838 mL	133.9190 mL
5 mM	0.5357 mL	2.6784 mL	5.3568 mL	26.7838 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2678 mL	1.3392 mL	2.6784 mL	13.3919 mL
20 mM	0.1339 mL	0.6696 mL	1.3392 mL	6.6960 mL
50 mM	0.0536 mL	0.2678 mL	0.5357 mL	2.6784 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc