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INT-767

Name: INT-767
Brand: TargetMol
SKU: T11661
Price: 399 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11661Cas No. 1000403-03-1

INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.

INT-767

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Purity: 98%

Catalog No. T11661Cas No. 1000403-03-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$399	-	In Stock
5 mg	$948	8-10 weeks	8-10 weeks
10 mg	$1,290	8-10 weeks	8-10 weeks
25 mg	$1,890	8-10 weeks	8-10 weeks
50 mg	$2,580	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.
In vitro	INT-767 does not inhibit hERG, indicating that this compound should not induce cardiac toxicity because of inhibition of the potassium channel[2].
In vivo	Mice were treated daily with INT-767 (10 and 20 mg/kg) or vehicle alone (40% 2-hydroxypropyl-β-cyclodextrin) via intraperitoneal injection for 2 weeks. The results showed that INT-767 reduced the levels of plasma total cholesterol, high-density lipoprotein cholesterol, and triglycerides in both db/m and db/db mice [2].

Chemical Properties

Molecular Weight	494.66
Formula	C₂₅H₄₃NaO₆S
Cas No.	1000403-03-1
Smiles	O[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCOS(=O)([O-])=O)C)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])[C@H]1CC)C.[Na+]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (161.73 mM), Sonication is recommended.

H2O: 80 mg/mL (161.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0216 mL	10.1080 mL	20.2159 mL	101.0795 mL
5 mM	0.4043 mL	2.0216 mL	4.0432 mL	20.2159 mL
10 mM	0.2022 mL	1.0108 mL	2.0216 mL	10.1080 mL
20 mM	0.1011 mL	0.5054 mL	1.0108 mL	5.0540 mL
50 mM	0.0404 mL	0.2022 mL	0.4043 mL	2.0216 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0108 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc