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Deoxycorticosterone

Name: Deoxycorticosterone
Brand: TargetMol
SKU: T20302
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20302Cas No. 64-85-7

Alias Desoxycortone, Desoxycorticosteronum, Desoxycorticosterone

Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

Deoxycorticosterone

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Purity: 98.19%

Catalog No. T20302Alias Desoxycortone, Desoxycorticosteronum, DesoxycorticosteroneCas No. 64-85-7

Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	Inquiry	In Stock	In Stock
50 mg	Inquiry	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.19%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Deoxycorticosterone AI Summary

Deoxycorticosterone exhibits a range of bioactivities, prominently featuring strong binding affinities towards transport and binding proteins such as corticosteroid-binding globulin and testosterone-binding globulin, with respective Log 1/K values of 7.653 and 7.38. It has a relative binding affinity of 58.0% against the Mineralocorticoid Receptor in male Sprague-Dawley rats, reflecting a mineralocorticoid activity value of 1.0 in this model. Additionally, it demonstrates significant permeability characteristics with a division coefficient (logD7.4) of 3.08 and a skin permeability log Kp of -6.73. The compound also shows specific interactions in various cellular and enzymatic contexts, such as notable antiviral activity against SARS-CoV-2, moderate inhibition of human HDAC6 (32.24% inhibition with a commercial peptide substrate), and the potential to influence hormone-related bioactivity through displacement of sex hormones from their binding globulins and interaction with the androgen and progestin receptors. Moreover, it inhibits mouse constitutive androstane receptor activity, with 58.0% of activity remaining at 10 μM. These diverse bioactivities suggest that Deoxycorticosterone may have substantial therapeutic and pharmacological potential across multiple biological pathways and targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.
Targets&IC50	Mineralocorticoid Receptor:0.16 nM (EC50)
Synonyms	Desoxycortone, Desoxycorticosteronum, Desoxycorticosterone

Chemical Properties

Molecular Weight	330.46
Formula	C₂₁H₃₀O₃
Cas No.	64-85-7
Smiles	C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
Relative Density.	1.15 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (287.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0261 mL	15.1304 mL	30.2608 mL	151.3042 mL
5 mM	0.6052 mL	3.0261 mL	6.0522 mL	30.2608 mL
10 mM	0.3026 mL	1.5130 mL	3.0261 mL	15.1304 mL
20 mM	0.1513 mL	0.7565 mL	1.5130 mL	7.5652 mL
50 mM	0.0605 mL	0.3026 mL	0.6052 mL	3.0261 mL
100 mM	0.0303 mL	0.1513 mL	0.3026 mL	1.5130 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc