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Anti-HSD11B2 Polyclonal Antibody 2

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Catalog No. TMAB-07312

Anti-HSD11B2 Polyclonal Antibody 2 is a Rabbit antibody targeting HSD11B2. Anti-HSD11B2 Polyclonal Antibody 2 can be used in WB,ELISA.

Anti-HSD11B2 Polyclonal Antibody 2

Anti-HSD11B2 Polyclonal Antibody 2

😃Good
Catalog No. TMAB-07312
Anti-HSD11B2 Polyclonal Antibody 2 is a Rabbit antibody targeting HSD11B2. Anti-HSD11B2 Polyclonal Antibody 2 can be used in WB,ELISA.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2237-10 days7-10 days
100 μL$3717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-HSD11B2 Polyclonal Antibody 2 is a Rabbit antibody targeting HSD11B2. Anti-HSD11B2 Polyclonal Antibody 2 can be used in WB,ELISA.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000; ELISA: 1:5000-10000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMicrosome. Endoplasmic reticulum.
Tissue SpecificityFound in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThere are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Antigen Details
Immunogen
Recombinant Protein: human HSD11B2 protein
Antigen Species
Human
Gene Name
HSD11B2
Gene ID
Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 2
Uniprot ID
Function
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Chemical Properties
Molecular WeightTheoretical: 45 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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