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Anti-ASF1B Antibody (1N1)
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Catalog No. TMAY-02727
Alias CIA-II, anti-silencing function 1B histone chaperone
Anti-ASF1B Antibody (1N1) is a Rabbit antibody targeting ASF1B. Anti-ASF1B Antibody (1N1) can be used in IHC-P.
Anti-ASF1B Antibody (1N1)
Anti-ASF1B Antibody (1N1)
😃Good
Catalog No. TMAY-02727Alias CIA-II, anti-silencing function 1B histone chaperone
Anti-ASF1B Antibody (1N1) is a Rabbit antibody targeting ASF1B. Anti-ASF1B Antibody (1N1) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ASF1B Antibody (1N1) is a Rabbit antibody targeting ASF1B. Anti-ASF1B Antibody (1N1) can be used in IHC-P. |
| Alias | CIA-II, anti-silencing function 1B histone chaperone |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1N1 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human ASF1B in human testis with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ASF1B in human small intestine with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human ASF1B (rh ASF1B; TMPY-03341; Q9NVP2; Met1-Ile202). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely related ASF1b and does not require its histone chaperone activity. Homozygous deletion of ASF1A is seen in 10%-15% of certain cancers, suggesting that loss of NHEJ may be selected in some malignancies and that the deletion can be used as a molecular biomarker for cancers susceptible to radiotherapy or to DSB-inducing chemotherapy. Anti-silencing function 1 (ASF1) is a histone H3-H4 chaperone involved in DNA replication and repair, and transcriptional regulation. Here, we identify ASF1B, the mammalian paralog to ASF1, as a proliferation-inducing histone chaperone in human β-cells. Overexpression of ASF1B led to distinct transcriptional signatures consistent with increased cellular proliferation and reduced cellular death. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human ASF1B Protein (TMPY-03341) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
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