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SJG-136

Name: SJG-136
Brand: TargetMol
SKU: T16890
Rating: 4.5 (1 reviews)

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Catalog No. T16890Cas No. 232931-57-6

Alias NSC-694501

SJG-136, a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA), is used for its capability to form covalent bonds between DNA strands.

SJG-136

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Catalog No. T16890Alias NSC-694501Cas No. 232931-57-6

SJG-136, a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA), is used for its capability to form covalent bonds between DNA strands.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,500	10-14 weeks	10-14 weeks
50 mg	$1,950	10-14 weeks	10-14 weeks
100 mg	$2,950	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SJG-136, a DNA cross-linking agent (XL50: 45 nM for pBR322 DNA), is used for its capability to form covalent bonds between DNA strands.
Targets&IC50	pBR322 DNA:（XL50）45 nM
In vitro	SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC50: 22.5 pM), A2780cisR (IC50: 24 pM), CH1 (IC50: 0.12 nM), CH1cisR (IC50: 0.6 nM), and SKOV-3 (IC50: 9.1 nM). SJG-136 also reduces the viability of a panel of canine cancer cells (GI50: ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure) [1][2].
In vivo	SJG-136-induced H2AX phosphorylation correlates well, albeit with lower sensitivity, compared to foci measurement. At a dosage of 0.30 mg/kg, SJG-136 exhibits a stronger antitumor effect on CMeC-1 tumors in mice than at 0.15 mg/kg, regardless of whether it is given as a single dose or once weekly for three weeks through intravenous administration [2].
Synonyms	NSC-694501

Chemical Properties

Molecular Weight	556.61
Formula	C₃₁H₃₂N₄O₆
Cas No.	232931-57-6
Smiles	COc1cc2c(cc1OCCCOc1cc3N=C[C@@H]4CC(=C)CN4C(=O)c3cc1OC)N=C[C@@H]1CC(=C)CN1C2=O
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (179.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7966 mL	8.9830 mL	17.9659 mL	89.8295 mL
5 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9659 mL
10 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9830 mL
20 mM	0.0898 mL	0.4491 mL	0.8983 mL	4.4915 mL
50 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL
100 mM	0.0180 mL	0.0898 mL	0.1797 mL	0.8983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc