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Nectin-2 Protein, Human, Recombinant

Catalog No. TMPY-00748
Synonyms: PRR2, Nectin-2, PVRR2, poliovirus receptor-related 2 (herpesvirus entry mediator B), HVEB, CD112

Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Nectin-2 Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
100 μg In stock $ 334.00
200 μg 5 days $ 573.00
500 μg 5 days $ 1,160.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information 1.Measured by its binding ability in a functional ELISA. Immobilized human CD112 at 10 μg/ml (100 μl/well) can bind human DNAM1-Fch with a linear range of 1.25-10 μg/ml. 2.Loaded Human PVRIG Protein, mFc Tag on AMC Biosensor, can bind Human Nectin-2 protein with an affinity constant of 0.680μM as determined in BLI assay (Routinely tested).

Description Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
Species Human
Expression System HEK293 Cells
Tag Tag Free
Accession Number Q92692-2
Synonyms PRR2, Nectin-2, PVRR2, poliovirus receptor-related 2 (herpesvirus entry mediator B), HVEB, CD112
Construction The mature form of recombinant Human CD112 (NP_002847.1) extracellular domain (Met 1-Leu 360) with quinary-aa peptide (DDDDK) at the C-terminus was expressed and purified.
Protein Purity ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Molecular Weight 36.2 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

References and Literature

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Keywords

Nectin-2 Protein, Human, Recombinant PRR2 Nectin-2 PVRR2 PVRR 2 poliovirus receptor-related 2 (herpesvirus entry mediator B) PRR 2 HVEB CD112 CD 112 herpesvirus entry mediator B PVRR-2 PRR-2 poliovirus receptor-related 2 CD-112 recombinant recombinant-proteins proteins protein

 

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