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Jatrorrhizine chloride

Name: Jatrorrhizine chloride
Brand: TargetMol
SKU: T4912
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4912Cas No. 6681-15-8

Alias Yatrorhizine chloride, Neprotine chloride

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

Jatrorrhizine chloride

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Purity: 99.79%

Catalog No. T4912Alias Yatrorhizine chloride, Neprotine chlorideCas No. 6681-15-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$92	In Stock	In Stock
50 mg	$157	In Stock	In Stock
100 mg	$233	In Stock	In Stock
500 mg	$553	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Targets&IC50	AChE:872 nM (IC50)
In vitro	Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT.
Synonyms	Yatrorhizine chloride, Neprotine chloride

Chemical Properties

Molecular Weight	373.8
Formula	C₂₀H₂₀ClNO₄
Cas No.	6681-15-8
Smiles	[Cl-].COc1cc-2c(CC[n+]3cc4c(OC)c(OC)ccc4cc-23)cc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (21.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6752 mL	13.3761 mL	26.7523 mL	133.7614 mL
5 mM	0.5350 mL	2.6752 mL	5.3505 mL	26.7523 mL
10 mM	0.2675 mL	1.3376 mL	2.6752 mL	13.3761 mL
20 mM	0.1338 mL	0.6688 mL	1.3376 mL	6.6881 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc