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Jatrorrhizine chloride

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Catalog No. T4912Cas No. 6681-15-8
Alias Yatrorhizine chloride, Neprotine chloride

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

Jatrorrhizine chloride
Other Forms of Jatrorrhizine chloride:

Jatrorrhizine chloride

🥰Excellent
Purity: 99.79%
Catalog No. T4912Alias Yatrorhizine chloride, Neprotine chlorideCas No. 6681-15-8
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$31In StockIn Stock
10 mg$51In StockIn Stock
25 mg$92In StockIn Stock
50 mg$157In StockIn Stock
100 mg$233In StockIn Stock
500 mg$553-In Stock
1 mL x 10 mM (in DMSO)$35In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.79%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
Targets&IC50
AChE:872 nM (IC50)
In vitro
Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT.
SynonymsYatrorhizine chloride, Neprotine chloride
Chemical Properties
Molecular Weight373.8
FormulaC20H20ClNO4
Cas No.6681-15-8
Smiles[Cl-].COc1cc-2c(CC[n+]3cc4c(OC)c(OC)ccc4cc-23)cc1O
Relative Density.no data available
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 8 mg/mL (21.4 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.68 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6752 mL13.3761 mL26.7523 mL133.7614 mL
5 mM0.5350 mL2.6752 mL5.3505 mL26.7523 mL
10 mM0.2675 mL1.3376 mL2.6752 mL13.3761 mL
20 mM0.1338 mL0.6688 mL1.3376 mL6.6881 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Yatrorhizine ChlorideSerotonin Receptorquaternary isoquinolinePMATOCTneuroprotectiveNeprotine ChlorideJatrorrhizine chlorideJatrorrhizine ChlorideJatrorrhizineInhibitorinhibitfalciparumE. histolyticadepressive disorderCytotoxicCholinesterase (ChE)Bacterialantiplasmodialantioxidantantimicrobialantidepressant-likeantidepressantantiamoebicAlzheimer's diseasealkaloidAChE5-hydroxytryptamine Receptor5HTReceptor5-HT Receptor5HT Receptor
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