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diABZI STING agonist-1 (Tautomerism)

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Catalog No. T11035Cas No. 2138498-18-5
Alias diABZI STING agonist (Compound 3)

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

diABZI STING agonist-1 (Tautomerism)
Other Forms of diABZI STING agonist-1 (Tautomerism):

diABZI STING agonist-1 (Tautomerism)

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Purity: 99.72%
Catalog No. T11035Alias diABZI STING agonist (Compound 3)Cas No. 2138498-18-5
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$148In StockIn Stock
2 mg$218In StockIn Stock
5 mg$372In StockIn Stock
10 mg$533In StockIn Stock
25 mg$786In StockIn Stock
50 mg$1,080In StockIn Stock
100 mg$1,460-In Stock
200 mg$1,980-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.72%
Appearance:Solid
Color:White to Yellow
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
Targets&IC50
H69AR cells:0.055 μM (EC50), STNG (mouse):186 nM (EC50), STNG (human, PBMC cells):130 nM (EC50), H69AR cells:0.035 μM (EC50)
In vitro
diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, respectively. diABZI STING agonist-1 (Tautomerism) at a concentration of 1 μM showed high selectivity for more than 350 kinases tested[1].
In vivo
diABZI STING agonist-1 (Tautomerism)(subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type I interferon and proinflammatory cytokines in vivo. diABZI STING agonist-1 (Tautomerism) (intravenous; 3 mg/kg) exhibited systemic exposure with a half-life of 1.4 hours and reached a systemic concentration greater than half the maximum effective concentration of STING in mice (EC50) 200 ng/kg) ml). diABZI STING agonist-1 (Tautomerism) (intravenous; 1.5 mg / kg; 43 days) can significantly inhibit tumor growth and significantly improve survival rate (P <0.001). Eight out of 10 mice are tumor-free[1].
SynonymsdiABZI STING agonist (Compound 3)
Chemical Properties
Molecular Weight849.94
FormulaC42H51N13O7
Cas No.2138498-18-5
SmilesC(/C=C/CN1C=2C(N=C1NC(=O)C=3N(CC)N=C(C)C3)=CC(C(N)=O)=CC2OC)N4C=5C(N=C4NC(=O)C=6N(CC)N=C(C)C6)=CC(C(N)=O)=CC5OCCCN7CCOCC7
Relative Density.1.44 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight,The compound is unstable in solution. Please use soon | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (117.66 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1766 mL5.8828 mL11.7655 mL58.8277 mL
5 mM0.2353 mL1.1766 mL2.3531 mL11.7655 mL
10 mM0.1177 mL0.5883 mL1.1766 mL5.8828 mL
20 mM0.0588 mL0.2941 mL0.5883 mL2.9414 mL
50 mM0.0235 mL0.1177 mL0.2353 mL1.1766 mL
100 mM0.0118 mL0.0588 mL0.1177 mL0.5883 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TautomerismSTINGdiABZI STING agonist-1diABZI STING agonistCompound 3
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