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Glutaminase C-IN-1

Name: Glutaminase C-IN-1
Brand: TargetMol
SKU: T3964
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3964Cas No. 311795-38-7

Alias Glutaminase Inhibitor Compound 968, Compound 968

Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C (GLS1).

Glutaminase C-IN-1

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Purity: 99.68%

Catalog No. T3964Alias Glutaminase Inhibitor Compound 968, Compound 968Cas No. 311795-38-7

Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C (GLS1).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$165	In Stock	In Stock
50 mg	$287	In Stock	In Stock
100 mg	$397	-	In Stock
200 mg	$587	-	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Glutaminase C-IN-1 AI Summary

Glutaminase C-IN-1 exhibits a diverse range of bioactivities, notably functioning as an antagonist for the NFkB signaling pathway with a potency of 667.7 nM. It possesses inhibitory effects on cell proliferation across various cell lines, including hMSC, TMD8, ED40515 IL2 dependent ATL cell lines, and Plasmodium falciparum, with potencies ranging from 525.8 nM to 37221.2 nM. Additionally, it shows sensitization or mitigation effects in immunotoxin studies within the potency range of 11770.4 nM to 37221.2 nM. Furthermore, Glutaminase C-IN-1 inhibits GAC enzyme activity, exhibiting an IC50 value of 9300.0 nM. These findings underscore its potential in multiple therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C (GLS1).
Synonyms	Glutaminase Inhibitor Compound 968, Compound 968

Chemical Properties

Molecular Weight	475.42
Formula	C₂₇H₂₇BrN₂O
Cas No.	311795-38-7
Smiles	CN(C)c1ccc(cc1Br)C1Nc2ccc3ccccc3c2C2=C1C(=O)CC(C)(C)C2
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.17 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1034 mL	10.5170 mL	21.0340 mL	105.1702 mL
5 mM	0.4207 mL	2.1034 mL	4.2068 mL	21.0340 mL
10 mM	0.2103 mL	1.0517 mL	2.1034 mL	10.5170 mL
20 mM	0.1052 mL	0.5259 mL	1.0517 mL	5.2585 mL
50 mM	0.0421 mL	0.2103 mL	0.4207 mL	2.1034 mL
100 mM	0.0210 mL	0.1052 mL	0.2103 mL	1.0517 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc