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DDD100097 (Synonyms: DDD-100097, DDD 100097)
Catalog No. T23973 Copy Product Info
Purity: 99.93%
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DDD100097 is a potent N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.
DDD100097
Copy Product Info😃Good
Catalog No. T23973
Synonyms DDD-100097, DDD 100097
DDD100097 is a potent N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.
Cas No. 1215012-74-0
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $210 | In Stock | In Stock | |
| 5 mg | $582 | In Stock | In Stock | |
| 10 mg | $720 | In Stock | In Stock | |
| 25 mg | $953 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
DDD100097 AI Summary
DDD100097 exhibits potent bioactivities in various assays. It shows high inhibitory activity against Trypanosoma brucei N-myristoyltransferase with an IC50 value of 2.0 nM and inhibits human N-myristoyltransferase 1 with an IC50 value of 12.0 nM. Demonstrating strong antitrypanosomal activity, it has an EC50 value of 1.0 nM against Trypanosoma brucei BSF427. However, its antiproliferative activity against human MRC5 cells is less pronounced, with an EC50 value of 1000.0 nM. The ratio of drug level in the brain to blood in wild-type NMRI mice is 1.6. The compound has a maximum tolerated dose of 100.0 mg/kg when administered orally twice daily to mice. Its intrinsic clearance in CD1 mouse liver microsomes is 2.5 mL·min-1·g-1. Additionally, it shows inhibitory activity against human ERG with an IC50 value of 600.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DDD100097 is a potent N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders. |
| Synonyms | DDD-100097, DDD 100097 |
| Molecular Weight | 523.47 |
| Formula | C22H30Cl2F2N4O2S |
| Cas No. | 1215012-74-0 |
| Smiles | N(S(=O)(=O)C1=C(Cl)C=C(CCCC2CCN(C)CC2)C=C1Cl)(C(F)F)C3=C(C)N(C)N=C3C |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (14.33 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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