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Okadaic acid

Name: Okadaic acid
Brand: TargetMol
SKU: T16381
Price: 200 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16381Cas No. 78111-17-8

Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer.

Okadaic acid

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Purity: 97.76%

Catalog No. T16381Cas No. 78111-17-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 μg (124.2 μM * 250 μL in Ethanol)"	$200	In Stock	-
50 μg (124.2 μM * 500 μL in Ethanol)	$300	35 days	35 days
100 μg (124.2 μM * 1 mL in Ethanol)	$460	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.76%

Color:Transparent

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COA HNMR HPLC IR MS

Product Introduction

Bioactivity

Description	Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer.
Targets&IC50	PP2:0.5 nM, PP7:>1000 nM, PP4:0.1 nM, PP1:15-50 nM, PP1:10-15 nM, PP2B:~4000 nM, PP3:3.7-4 nM, PP3:4 nM, PP2A:0.1-0.3 nM, PP5:3.5 nM
In vitro	Okadaic acid, at concentrations ranging from 0 to 100 nM and after treatment periods of 24 or 48 hours, is capable of inhibiting the proliferation of AGS, MNK-45, and Caco 2 cells[3].
In vivo	Okadaic Acid (100 μg; icv; single dose) can be used in male Wistar rats (250-300 g) to establish an Alzheimer's disease model[6].
Disease Modeling Protocol	Establishment of Alzheimer's disease model Modeling Mechanism： Okadaic Acid is a Ser/Thr phosphatase inhibitor that can cause Tau hyperphosphorylation and induce intracellular aggregation of neurofibrillary tangles. Related Products： Okadaic acid ammonium salt (T39183). Modeling Method： Experimental Subject：Mouse • Wistar • Male • 250-300 g Dosage and Administration Route：100 μg • icv (intracerebroventricular injection) Dosing Frequency and Duration Model：Single dose Validation： Molecular changes: induction of increased pTau ser396 in the hippocampus. Precautions： The above data are from literature and for reference only. It is recommended to determine the optimal experimental conditions based on preliminary experiments. References：Dos Santos Tramontin N,et,al. Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer's Disease Model. Mol Neurobiol. 2020 Feb;57(2):926-936.

Chemical Properties

Molecular Weight	805
Formula	C₄₄H₆₈O₁₃
Cas No.	78111-17-8
Smiles	O[C@H]1[C@@]2(O[C@]([C@@H](/C=C/[C@@H]3O[C@]4(CC3)O[C@@]5([C@@](CC4)(O[C@]([C@H](C[C@H](C)[C@]6(O[C@]7(CC[C@H]6C)CCCCO7)[H])O)(C(=C)[C@H]5O)[H])[H])[H])C)(CC(C)=C2)[H])O[C@H](C[C@@](C(O)=O)(C)O)CC1
Relative Density.	1.0795 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc