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Okadaic acid
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Catalog No. T16381Cas No. 78111-17-8
Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer.
Okadaic acid
😃Good
Catalog No. T16381Cas No. 78111-17-8
Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μg (124.2 μM * 250 μL in Ethanol)" | $200 | In Stock | |
| 50 μg (124.2 μM * 500 μL in Ethanol) | $300 | 35 days | |
| 100 μg (124.2 μM * 1 mL in Ethanol) | $460 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer. |
| Targets&IC50 | PP7:>1000 nM, PP5:3.5 nM, PP2A:0.1-0.3 nM, PP3:4 nM, PP3:3.7-4 nM, PP1:10-15 nM, PP4:0.1 nM, PP2:0.5 nM, PP1:15-50 nM, PP2B:~4000 nM |
| In vitro | Okadaic acid, at concentrations ranging from 0 to 100 nM and after treatment periods of 24 or 48 hours, is capable of inhibiting the proliferation of AGS, MNK-45, and Caco 2 cells[3]. |
| In vivo | Okadaic Acid (100 μg; icv; single dose) can be used in male Wistar rats (250-300 g) to establish an Alzheimer's disease model[6]. |
| Disease Modeling Protocol | Establishment of Alzheimer's disease model
*Precautions： The above data are from literature and for reference only. It is recommended to determine the optimal experimental conditions based on preliminary experiments. |
| Molecular Weight | 805 |
| Formula | C44H68O13 |
| Cas No. | 78111-17-8 |
| Smiles | O[C@H]1[C@@]2(O[C@]([C@@H](/C=C/[C@@H]3O[C@]4(CC3)O[C@@]5([C@@](CC4)(O[C@]([C@H](C[C@H](C)[C@]6(O[C@]7(CC[C@H]6C)CCCCO7)[H])O)(C(=C)[C@H]5O)[H])[H])[H])C)(CC(C)=C2)[H])O[C@H](C[C@@](C(O)=O)(C)O)CC1 |
| Relative Density. | 1.0795 g/cm3 (Estimated) |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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