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8-iso-15-keto Prostaglandin F2β

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Catalog No. T36167Cas No. 1621482-36-7
Alias 8-iso-15-keto Prostaglandin F2β

8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β.

8-iso-15-keto Prostaglandin F2β

8-iso-15-keto Prostaglandin F2β

😃Good
Catalog No. T36167Alias 8-iso-15-keto Prostaglandin F2βCas No. 1621482-36-7
8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 μg$19835 days35 days
500 μg$75335 days35 days
1 mg$1,28035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Bioactivity
Description
8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β.
Synonyms8-iso-15-keto Prostaglandin F2β
Chemical Properties
Molecular Weight352.471
FormulaC20H32O5
Cas No.1621482-36-7
Relative Density.1.149 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (141.86 mM), Sonication is recommended.
Ethanol: 50 mg/mL (141.86 mM), Sonication is recommended.
DMF: 50 mg/mL (141.86 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.84 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMSO/Ethanol/DMF
1mg5mg10mg50mg
1 mM2.8371 mL14.1856 mL28.3711 mL141.8556 mL
DMSO/Ethanol/DMF
1mg5mg10mg50mg
5 mM0.5674 mL2.8371 mL5.6742 mL28.3711 mL
10 mM0.2837 mL1.4186 mL2.8371 mL14.1856 mL
20 mM0.1419 mL0.7093 mL1.4186 mL7.0928 mL
50 mM0.0567 mL0.2837 mL0.5674 mL2.8371 mL
100 mM0.0284 mL0.1419 mL0.2837 mL1.4186 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

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