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Keap1-Nrf2-IN-15

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Catalog No. T78697Cas No. 2456295-45-5

Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1].

Keap1-Nrf2-IN-15

Keap1-Nrf2-IN-15

😃Good
Catalog No. T78697Cas No. 2456295-45-5
Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5208-10 weeks8-10 weeks
50 mg$1,9808-10 weeks8-10 weeks
100 mg$2,5008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1].
In vitro
Keap1-Nrf2-IN-15 (Compound 24a) binds to Keap1 protein [1] and, at concentrations of 10 and 100 μM for 24 hours, significantly induces the expression of Nrf2 target genes (HMOX1, GSTM3, NQO1) in NCM460D cells [1].
Chemical Properties
Molecular Weight801.84
FormulaC39H35N3O12S2
Cas No.2456295-45-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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