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Anti-Syndecan-1 Antibody-APC (1I989)

🥰Excellent
Catalog No. TMAY-01863A

Anti-Syndecan-1 Antibody-APC (1I989) is a APC-conjugated Rabbit antibody targeting Syndecan-1. Anti-Syndecan-1 Antibody-APC (1I989) can be used in FCM.

Anti-Syndecan-1 Antibody-APC (1I989)

Anti-Syndecan-1 Antibody-APC (1I989)

🥰Excellent
Catalog No. TMAY-01863A
Anti-Syndecan-1 Antibody-APC (1I989) is a APC-conjugated Rabbit antibody targeting Syndecan-1. Anti-Syndecan-1 Antibody-APC (1I989) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-Syndecan-1 Antibody-APC (1I989) is a APC-conjugated Rabbit antibody targeting Syndecan-1. Anti-Syndecan-1 Antibody-APC (1I989) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
Clone
1I989
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human SDC1(CD138) expression on RPMI8226 cells. Cells were stained with APC-conjugated anti-Human SDC1(CD138). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
10 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human Syndecan-1/SDC1 (rh Syndecan-1/SDC1; TMPY-01630; NP_002988.3; Met1-Glu251) and conjugated with APC under optimum conditions, the unreacted APC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Research BackgroundSyndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
Related Conjugates and Formulations
Conjucates
APC
Others Formats
Unconjugated/PerCP/FITC/PE
Antibody Types Available
5
Antigen Details
Immunogen
Recombinant Human Syndecan-1/SDC1 Protein (TMPY-01630)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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