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HIF-2α-IN-2

Name: HIF-2α-IN-2
Brand: TargetMol
SKU: T11561
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11561Cas No. 1672666-82-8

HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor with an IC50 of 16 nM in scintillation proximity assay (SPA).

HIF-2α-IN-2

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Purity: 99.24%

Catalog No. T11561Cas No. 1672666-82-8

HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor with an IC50 of 16 nM in scintillation proximity assay (SPA).

Pack Size	Price	Availability
1 mg	$46	In Stock
5 mg	$96	In Stock
10 mg	$132	In Stock
25 mg	$228	In Stock
50 mg	$329	In Stock
100 mg	$457	In Stock
1 mL x 10 mM (in DMSO)	$106	In Stock

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Batch Information

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Purity:99.24%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor with an IC50 of 16 nM in scintillation proximity assay (SPA).
Targets&IC50	HIF2α:16 nM

Chemical Properties

Molecular Weight	365.35
Formula	C₁₇H₁₃F₂NO₄S
Cas No.	1672666-82-8
Smiles	CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2CC(F)C(O)c12
Relative Density.	1.52 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (273.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7371 mL	13.6855 mL	27.3710 mL	136.8551 mL
5 mM	0.5474 mL	2.7371 mL	5.4742 mL	27.3710 mL
10 mM	0.2737 mL	1.3686 mL	2.7371 mL	13.6855 mL
20 mM	0.1369 mL	0.6843 mL	1.3686 mL	6.8428 mL
50 mM	0.0547 mL	0.2737 mL	0.5474 mL	2.7371 mL
100 mM	0.0274 mL	0.1369 mL	0.2737 mL	1.3686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc