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Halofantrine hydrochloride

Name: Halofantrine hydrochloride
Brand: TargetMol
SKU: T15460
Price: 128 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15460Cas No. 36167-63-2

Alias WR-171669 hydrochloride, SKF-102886

Halofantrine hydrochloride (SKF-102886) is an orally administered antimalarial drug effective against drug-resistant P. falciparum and P. vivax. SKF-102886 has cardiac toxicity, inhibiting hERG and delayed rectifier potassium channel I Kr, leading to prolonged QTc and PR intervals.

Halofantrine hydrochloride

🥰Excellent

Catalog No. T15460Alias WR-171669 hydrochloride, SKF-102886Cas No. 36167-63-2

Pack Size	Price	Availability	Quantity
1 mg	$128	In Stock

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Product Introduction

Bioactivity

Description	Halofantrine hydrochloride (SKF-102886) is an orally administered antimalarial drug effective against drug-resistant P. falciparum and P. vivax. SKF-102886 has cardiac toxicity, inhibiting hERG and delayed rectifier potassium channel I Kr, leading to prolonged QTc and PR intervals.
Synonyms	WR-171669 hydrochloride, SKF-102886

Chemical Properties

Molecular Weight	536.89
Formula	C₂₆H₃₁Cl₃F₃NO
Cas No.	36167-63-2
Smiles	Cl.FC(F)(F)C1=CC=C2C(=C1)C=3C=C(Cl)C=C(Cl)C3C=C2C(O)CCN(CCCC)CCCC
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (44.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8626 mL	9.3129 mL	18.6258 mL	93.1289 mL
5 mM	0.3725 mL	1.8626 mL	3.7252 mL	18.6258 mL
10 mM	0.1863 mL	0.9313 mL	1.8626 mL	9.3129 mL
20 mM	0.0931 mL	0.4656 mL	0.9313 mL	4.6564 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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