Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1]. |
Targets&IC50 | HPK1:3.5 nM |
In vitro | HPK1-IN-35 (compound 31) diminishes the expression of p-SLP76 stimulated by anti-CD3 antibody (1 µg/mL) in a dose-dependent manner at concentrations of 0.1, 0.3, 1, and 3 µM after 1 hour of treatment [1]. Additionally, HPK1-IN-35 enhances IL-2 secretion from Jurkat cells dose-dependently within the range of 0-10 µM over 24 hours, with an EC50 value of 1.19 µM [1]. |
Molecular Weight | 584.69 |
Formula | C30H32N8O3S |
CAS No. | 2935903-77-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HPK1-IN-35 2935903-77-6 inhibitor inhibit