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Anti-PLCG1 Antibody (1F907)
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Catalog No. TMAB-11535
Anti-PLCG1 Antibody (1F907) is a Rabbit antibody targeting PLCG1. Anti-PLCG1 Antibody (1F907) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Anti-PLCG1 Antibody (1F907)
Anti-PLCG1 Antibody (1F907)
Copy Product Info😃Good
Catalog No. TMAB-11535
Anti-PLCG1 Antibody (1F907) is a Rabbit antibody targeting PLCG1. Anti-PLCG1 Antibody (1F907) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Antigen Details
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| Description | Anti-PLCG1 Antibody (1F907) is a Rabbit antibody targeting PLCG1. Anti-PLCG1 Antibody (1F907) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF. |
| Ig Type | IgG |
| Clone | 1F907 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Testis tissue lysates Lane 3: Mouse NIH/3T3 cell lysates Lane 4: Rat Cerebrum tissue lysates Lane 5: Rat Testis tissue lysates Lane 6: Human A431 cell lysates Lane 7: Human A549 cell lysates Lane 8: Human MCF-7 cell lysates Lane 9: Human HeLa cell lysates Primary: Anti-PLCG1 (TMAB-11535) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 148 kDa Observed band size: 155 kDa |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | Recombinant Protein: human Phospholipase C gamma 1 protein, around C-terminal 150aa |
| Antigen Species | Human |
| Gene Name | PLCG1 |
| Gene ID | |
| Protein Name | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1 |
| Uniprot ID | |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. |
| Molecular Weight | Theoretical: 148 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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