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IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His)
(Synonyms: interleukin 11 receptor subunit α, interleukin 11 receptor subunit alpha, IL11RA) Copy Product InfoSynonyms: interleukin 11 receptor subunit α, interleukin 11 receptor subunit alpha, IL11RA
Catalog No. TMPY-04097 Copy Product Info
IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.4 kDa and the accession number is A0A8C0MDY4.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $68 | 7-10 days | 7-10 days | |
| 10 µg | $108 | 7-10 days | 7-10 days | |
| 20 µg | $178 | 7-10 days | 7-10 days | |
| 50 µg | $359 | 7-10 days | 7-10 days | |
| 100 µg | $696 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.4 kDa and the accession number is A0A8C0MDY4. |
| Species | Canine |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | A0A8C0MDY4 |
| Construction | A DNA sequence encoding the canine IL11RA (XP_005626799.1) (Met1-Leu363) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Val 23 |
| Protein Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | interleukin 11 receptor subunit α, interleukin 11 receptor subunit alpha, IL11RA |
| Research Background | Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to the ciliary neurotrophic factor since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11, and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. |
| Molecular Weight | 38.4 kDa (predicted); 47.7 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His) chemical structure | IL-11R alpha/IL-11RA Protein, Canine, Recombinant (His) molecular weight
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