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GAT211
🥰Excellent
Catalog No. T27405Cas No. 102704-40-5
Alias GAT-211, GAT 211, AZ-4, AZ4, AZ 4
GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.
GAT211
🥰Excellent
Purity: 99.7%
Catalog No. T27405Alias GAT-211, GAT 211, AZ-4, AZ4, AZ 4Cas No. 102704-40-5
GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $97 | In Stock | |
| 25 mg | $159 | In Stock | |
| 50 mg | $233 | In Stock | |
| 100 mg | $345 | In Stock | |
| 500 mg | $833 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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Purity:99.7%
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Product Introduction
Bioactivity
Chemical Properties
| Description | GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy. |
| In vitro | GAT211 limits dopamine D2 receptor-mediated extracellular signal-regulated kinase (ERK) phosphorylation in Neuro2a cells, while THC does not[2]. |
| In vivo | When administered alone, GAT211 treatment (0.3-3.0 mg/kg) dose-dependently reduces locomotor activity and acoustic startle response. GAT211 (3.0 mg/kg) also prevents MK-801-induced hyperlocomotion but has no significant effect on PPI impairment[2]. |
| Synonyms | GAT-211, GAT 211, AZ-4, AZ4, AZ 4 |
| Molecular Weight | 342.39 |
| Formula | C22H18N2O2 |
| Cas No. | 102704-40-5 |
| Smiles | [O-][N+](=O)CC(c1c([nH]c2ccccc12)-c1ccccc1)c1ccccc1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (233.65 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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