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GAT211

Name: GAT211
Brand: TargetMol
SKU: T27405
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27405Cas No. 102704-40-5

Alias GAT-211, GAT 211, AZ-4, AZ4, AZ 4

GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.

GAT211

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Purity: 99.7%

Catalog No. T27405Alias GAT-211, GAT 211, AZ-4, AZ4, AZ 4Cas No. 102704-40-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$159	In Stock	In Stock
50 mg	$233	In Stock	In Stock
100 mg	$345	In Stock	In Stock
500 mg	$833	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.7%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GAT211 (AZ-4) is a selective and potent cannabinoid 1 receptor (CB1R) orthosteric modulator (PAM) with high affinity for cAMP and β-arrestin2.GAT211 has IOP-lowering and antipsychotic effects and can be used in the study of epilepsy.
In vitro	GAT211 limits dopamine D2 receptor-mediated extracellular signal-regulated kinase (ERK) phosphorylation in Neuro2a cells, while THC does not[2].
In vivo	When administered alone, GAT211 treatment (0.3-3.0 mg/kg) dose-dependently reduces locomotor activity and acoustic startle response. GAT211 (3.0 mg/kg) also prevents MK-801-induced hyperlocomotion but has no significant effect on PPI impairment[2].
Synonyms	GAT-211, GAT 211, AZ-4, AZ4, AZ 4

Chemical Properties

Molecular Weight	342.39
Formula	C₂₂H₁₈N₂O₂
Cas No.	102704-40-5
Smiles	[O-][N+](=O)CC(c1c([nH]c2ccccc12)-c1ccccc1)c1ccccc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (233.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9206 mL	14.6032 mL	29.2065 mL	146.0323 mL
5 mM	0.5841 mL	2.9206 mL	5.8413 mL	29.2065 mL
10 mM	0.2921 mL	1.4603 mL	2.9206 mL	14.6032 mL
20 mM	0.1460 mL	0.7302 mL	1.4603 mL	7.3016 mL
50 mM	0.0584 mL	0.2921 mL	0.5841 mL	2.9206 mL
100 mM	0.0292 mL	0.1460 mL	0.2921 mL	1.4603 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc