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Anti-CEACAM5 Antibody-PE (3C451)
🥰Excellent
Catalog No. TMAY-01606P
Anti-CEACAM5 Antibody-PE (3C451) is a PE-conjugated Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody-PE (3C451) can be used in FCM.
Anti-CEACAM5 Antibody-PE (3C451)
Anti-CEACAM5 Antibody-PE (3C451)
🥰Excellent
Catalog No. TMAY-01606P
Anti-CEACAM5 Antibody-PE (3C451) is a PE-conjugated Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody-PE (3C451) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CEACAM5 Antibody-PE (3C451) is a PE-conjugated Rabbit antibody targeting CEACAM5. Anti-CEACAM5 Antibody-PE (3C451) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3C451 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of anti-Human CEACAM5 on HT29 cells. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM5 / CD66e (rh CEACAM5 / CD66e; TMPY-01647; NP_004354.2; Met1-Ala685) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | CEACAM5, also known as CEA or CD66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CEACAM5 / CD66e protein (TMPY-01647) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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