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Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2
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Catalog No. TMAB-11319
Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SREBP2 (Thr334). Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2 can be used in WB.
Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2
Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2
Copy Product Info😃Good
Catalog No. TMAB-11319
Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SREBP2 (Thr334). Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2 can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-SREBP2 (Thr334). Anti-Phospho-SREBP2 (Thr334) Polyclonal Antibody 2 can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Pig,Cow,Horse) |
| Verified Activity | Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Rat Testis tissue lysates Lane 3: Human HeLa cell lysates Lane 4: Human Raji cell lysates Lane 5: Human HepG2 cell lysates Primary: Anti-Phospho-SREBP2 (Thr334) (TMAB-11319) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 126 kDa Observed band size: 130 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Processed sterol regulatory element-binding protein 2: Nucleus. |
| Tissue Specificity | Ubiquitously expressed in adult and fetal tissues. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human SREBP2 around the phosphorylation site of Thr334 |
| Antigen Species | Human |
| Gene Name | SREBF2 |
| Gene ID | |
| Protein Name | Sterol regulatory element-binding protein 2 |
| Uniprot ID | |
| Function | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. |
| Molecular Weight | Theoretical: 126 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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