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Ponalrestat

Name: Ponalrestat
Brand: TargetMol
SKU: T2013
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2013Cas No. 72702-95-5

Ponalrestat is an aldose reductase inhibitor.

Ponalrestat

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Purity: 99.86%

Catalog No. T2013Cas No. 72702-95-5

Ponalrestat is an aldose reductase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$64	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Color:White

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Product Introduction

Ponalrestat AI Summary

Ponalrestat shows inhibitory activity against aldose reductase (AR) from various sources, including rat and porcine lenses, human placenta, and recombinant forms, with IC50 values ranging from 7.0 nM to 66.5 nM. It demonstrates differential inhibitory effectiveness against various mutant forms of aldose reductase, suggesting potential for selective bioactivity. The compound also shows significant inhibition of sorbitol accumulation in rat sciatic nerves in vitro and in vivo, with an ED50 of 4.0 mg/kg/day for aldose reductase inhibition. Additionally, Ponalrestat exhibits inhibition of other enzymes such as L-Hexonate Dehydrogenase (L-HDH) from rat kidney and has been observed to inhibit sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells. Furthermore, while it shows moderate antiviral activity against SARS-CoV-2 with an IC50 value greater than 20000.0 nM, its potential therapeutic applications span various biochemical pathways, indicating a broad spectrum of bioactivities, including lipid storage modulation, Cytochrome P450 inhibition, and potential implications in diabetic neuropathy due to its prolonged and dose-dependent inhibitory effects on sorbitol accumulation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ponalrestat is an aldose reductase inhibitor.
Targets&IC50	ALR2:7.7 nM (Ki), ALR1:60 μM (Ki)

Chemical Properties

Molecular Weight	391.19
Formula	C₁₇H₁₂BrFN₂O₃
Cas No.	72702-95-5
Smiles	OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2ccccc12
Relative Density.	1.60 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (115.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5563 mL	12.7815 mL	25.5630 mL	127.8151 mL
5 mM	0.5113 mL	2.5563 mL	5.1126 mL	25.5630 mL
10 mM	0.2556 mL	1.2782 mL	2.5563 mL	12.7815 mL
20 mM	0.1278 mL	0.6391 mL	1.2782 mL	6.3908 mL
50 mM	0.0511 mL	0.2556 mL	0.5113 mL	2.5563 mL
100 mM	0.0256 mL	0.1278 mL	0.2556 mL	1.2782 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc