Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

(S,R,S)-AHPC-C6-PEG3-C4-Cl

Name: (S,R,S)-AHPC-C6-PEG3-C4-Cl
Brand: TargetMol
SKU: T17911
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T17911Cas No. 1835705-55-9

Alias VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8

(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC based VHL ligand and a 3-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-C6-PEG3-C4-Cl

Copy Product Info

😃Good

Catalog No. T17911Alias VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8Cas No. 1835705-55-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$61	5 days	5 days
5 mg	$98	Inquiry	Inquiry

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC based VHL ligand and a 3-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro	The chemical compound '(S,R,S)-AHPC-C6-PEG3-C4-Cl' utilizes the cereblon ligand[1] and features a 6-2-2-6 linker, incorporating both hydrophobic and hydrophilic elements to achieve a balanced hydrophilicity/hydrophobicity in the resultant compounds. This compound forms the basis for developing PROTACs aimed at degrading the oncogenic tyrosine kinase BCR-ABL. It is engineered to attach to potent TKIs, specifically bosutinib and dasatinib, facilitating the degradation of c-ABL and BCR-ABL by exploiting either CRBN or VHL E3 ubiquitin ligase mechanisms[2].
Synonyms	VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8

Chemical Properties

Molecular Weight	751.42
Formula	C₃₈H₅₉ClN₄O₇S
Cas No.	1835705-55-9
Smiles	C([C@@H](NC(CCCCCOCCOCCOCCCCCCCl)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Relative Density.	1.174 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (133.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3308 mL	6.6541 mL	13.3081 mL	66.5407 mL
5 mM	0.2662 mL	1.3308 mL	2.6616 mL	13.3081 mL
10 mM	0.1331 mL	0.6654 mL	1.3308 mL	6.6541 mL
20 mM	0.0665 mL	0.3327 mL	0.6654 mL	3.3270 mL
50 mM	0.0266 mL	0.1331 mL	0.2662 mL	1.3308 mL
100 mM	0.0133 mL	0.0665 mL	0.1331 mL	0.6654 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc