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(S,R,S)-AHPC-C6-PEG3-C4-Cl

Name: (S,R,S)-AHPC-C6-PEG3-C4-Cl
Brand: TargetMol
SKU: T17911
Rating: 4.5 (1 reviews)

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Catalog No. T17911Cas No. 1835705-55-9

Alias VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8

(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC based VHL ligand and a 3-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-C6-PEG3-C4-Cl

😃Good

Catalog No. T17911Alias VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8Cas No. 1835705-55-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$61	5 days	5 days
5 mg	$98	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC based VHL ligand and a 3-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
In vitro	The chemical compound '(S,R,S)-AHPC-C6-PEG3-C4-Cl' utilizes the cereblon ligand[1] and features a 6-2-2-6 linker, incorporating both hydrophobic and hydrophilic elements to achieve a balanced hydrophilicity/hydrophobicity in the resultant compounds. This compound forms the basis for developing PROTACs aimed at degrading the oncogenic tyrosine kinase BCR-ABL. It is engineered to attach to potent TKIs, specifically bosutinib and dasatinib, facilitating the degradation of c-ABL and BCR-ABL by exploiting either CRBN or VHL E3 ubiquitin ligase mechanisms[2].
Synonyms	VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8

Chemical Properties

Molecular Weight	751.42
Formula	C₃₈H₅₉ClN₄O₇S
Cas No.	1835705-55-9
Relative Density.	1.174 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (133.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.39 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3308 mL	6.6541 mL	13.3081 mL	66.5407 mL
5 mM	0.2662 mL	1.3308 mL	2.6616 mL	13.3081 mL
10 mM	0.1331 mL	0.6654 mL	1.3308 mL	6.6541 mL
20 mM	0.0665 mL	0.3327 mL	0.6654 mL	3.3270 mL
50 mM	0.0266 mL	0.1331 mL	0.2662 mL	1.3308 mL
100 mM	0.0133 mL	0.0665 mL	0.1331 mL	0.6654 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc