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VP-14637

Name: VP-14637
Brand: TargetMol
SKU: T21560
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21560Cas No. 235106-62-4

Alias VP14637, MDT-637, MDT637

VP-14637, also known as MDT 637, is a small-molecule respiratory syncytial virus inhibitor that exhibits potent antiviral activity with an EC50 value of 1.4 nM, VP-14637 inhibits viral fusion through defined molecular mechanisms, making it a valuable tool for antiviral drug research and mechanistic studies of RSV entry and replication.

VP-14637

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Purity: 99.80%

Catalog No. T21560Alias VP14637, MDT-637, MDT637Cas No. 235106-62-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	-	In Stock
5 mg	$196	-	In Stock
10 mg	$293	-	In Stock
25 mg	$498	-	In Stock
50 mg	$696	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.80%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VP-14637, also known as MDT 637, is a small-molecule respiratory syncytial virus inhibitor that exhibits potent antiviral activity with an EC50 value of 1.4 nM, VP-14637 inhibits viral fusion through defined molecular mechanisms, making it a valuable tool for antiviral drug research and mechanistic studies of RSV entry and replication.
In vitro	In cellular assays, VP-14637 demonstrates broad-spectrum activity across various RSV genotypes. It inhibits viral replication in laboratory strains, such as RSV-A Long and RSV-A2, as well as in clinical isolates like RSV-Memphis-37. The observed IC₅₀ values range from 0.36 to 3.4 ng/mL, with a mean IC₅₀ of approximately 1.42 ng/mL [1].
Synonyms	VP14637, MDT-637, MDT637

Chemical Properties

Molecular Weight	510.51
Formula	C₂₅H₂₂N₁₀O₃
Cas No.	235106-62-4
Smiles	OC1=CC=C(C=C1)C(C2=CC(C=NN3N=NN=C3C)=CC=C2O)C4=CC(C=NN5N=NN=C5C)=CC=C4O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (195.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9588 mL	9.7941 mL	19.5883 mL	97.9413 mL
5 mM	0.3918 mL	1.9588 mL	3.9177 mL	19.5883 mL
10 mM	0.1959 mL	0.9794 mL	1.9588 mL	9.7941 mL
20 mM	0.0979 mL	0.4897 mL	0.9794 mL	4.8971 mL
50 mM	0.0392 mL	0.1959 mL	0.3918 mL	1.9588 mL
100 mM	0.0196 mL	0.0979 mL	0.1959 mL	0.9794 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc