Skin Disease Modeling

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Disease Modeling

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Dermatological Disease Modeling Products are widely used in establishing models of psoriasis, atopic dermatitis, skin cancer, and other skin-related disorders. TargetMol offers inducers such as IMQ (Imiquimod), IL-17/IL-23, Capsaicin, and Terephthalic acid, which are suitable for modeling chronic inflammatory skin diseases and skin tumors. These products support the exploration of disease mechanisms and the development of topical therapeutics for dermatological conditions.

IL-23 Protein, Mouse, Recombinant (His)

TMPY-03526

Expression system: HEK293 Cells
Length: 1-196 & 1-335, Full Length
Activity: ELISA、Cells

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SPR-compatible buffer

Capsaicin

T1062404-86-4

Capsaicin is an active natural component found in chili peppers and acts as a TRPV1 agonist (EC50 = 0.29 μM). It possesses multiple activities, including pain relief, antitumor, anti-inflammatory, antioxidant, and neuroprotective effects, as well as some neurotoxicity. Capsaicin can be used to establish itch models.

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Calcipotriol

T14856112965-21-6

Calcipotriol (MC 903) is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor.

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Imiquimod hydrochloride

T2209199011-78-6

Imiquimod hydrochloride (R 837 hydrochloride) is a selective toll-like receptor 7 (TLR7) agonist and immune response modulator with antiviral and antitumor activities. It is used in the study of external genital warts, perianal warts, cancer, COVID-19, pemphigus foliaceus, skin cancer, and psoriasis, and is commonly employed to establish psoriasis models.

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DMBA

T3669657-97-6

DMBA (7,12-Dimethylbenz[a]anthracene) is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that can be used to induce animal models of leukemia, liver cancer, breast cancer, skin cancer, and lung cancer. It is also capable of inducing programmed cell death (apoptosis) in A20.1 murine B-cell lymphoma.

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Imiquimod

T013499011-02-6

Imiquimod (R 837) is an immune response modifier and a toll-like receptor 7 (TLR7) agonist with antiviral and antitumor effects. It is used in the study of external genital warts, perianal warts, cancer, and COVID-19, and is commonly employed to induce psoriasis models.

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Oxazolone

T509515646-46-5

Oxazolone is a haptenating agent that can induce models of acute or chronic colitis and atopic dermatitis. It activates Th1 Th2 responses, leading to weight loss and diarrhea, and the resulting inflammation can be alleviated by anti-IL-4 antibodies, anti-TNF-α antibodies, or IL-13R2α-Fc fusion proteins. It is also suitable for studying gene expression related to inflammatory bowel disease in zebrafish.

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Imiquimod maleate

T22862896106-16-4

Imiquimod maleate (R 837 maleate) is a toll-like receptor 7 (TLR7) agonist and immune response modifier with antiviral and antitumor activities. It is used in the study of external genital warts, perianal warts, cancer, and COVID-19, and can induce psoriasis-like skin lesions in mice, commonly used to establish psoriasis models.

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IL-17 Protein, Mouse, Recombinant (His)

TMPJ-01172

Expression system: HEK293 Cells
Length: 22-158, Partial
Activity: BLI、Cells

7-10 days

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SPR-compatible buffer

Imiquimod 2HCl

T0134L2995277-02-4

Imiquimod 2HCl is a toll-like receptor 7 (TLR7) agonist and immune modulator with antiviral and antitumor activities. It can be used to establish psoriasis-like mouse models and for the study of periorbital skin cancer, pemphigus foliaceus, and COVID-19.

$195

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