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Luffariellolide

Name: Luffariellolide
Brand: TargetMol
SKU: T21893
Rating: 4.5 (1 reviews)

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Catalog No. T21893Cas No. 111149-87-2

Luffariellolide is a terpene compound obtained from the marine sponge Hyrtios communis. It is an inhibitor of human synoviocyte protein phospholipase A2 (HSF-PLA2) and a retinoic acid receptor (RAR) agonist. Luffariellolide inhibits hypoxia (1% O2)-induced HIF-1 activation and inhibits cell growth.

Luffariellolide

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Purity: 98%

Catalog No. T21893Cas No. 111149-87-2

Pack Size	Price	Availability	Quantity
1 mg	$673	35 days

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Purity:98%

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Product Introduction

Bioactivity

Description	Luffariellolide is a terpene compound obtained from the marine sponge Hyrtios communis. It is an inhibitor of human synoviocyte protein phospholipase A2 (HSF-PLA2) and a retinoic acid receptor (RAR) agonist. Luffariellolide inhibits hypoxia (1% O2)-induced HIF-1 activation and inhibits cell growth.
Targets&IC50	Bee venom phospholipase A2:0.23 μM
In vitro	Luffariellolide inhibited in vitro hydrolysis of phosphatidyl choline by purified bee venom phospholipase A2 (IC50 = 0.23 μM). [1]

Chemical Properties

Molecular Weight	386.57
Formula	C₂₅H₃₈O₃
Cas No.	111149-87-2
Smiles	C(C/C(=C/CC/C(=C/CCC1=CC(=O)OC1O)/C)/C)C=2C(C)(C)CCCC2C
Relative Density.	1.31g/cm3
Color	Yellow
Appearance	Oil

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc