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WL47 TFA

Name: WL47 TFA
Brand: TargetMol
SKU: T78373
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78373

Alias WL 47 TFA

WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.

WL47 TFA

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Purity: 99.80%

Catalog No. T78373Alias WL 47 TFA

WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.80%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.
Targets&IC50	caveolin-1 ligand:23 nM (Kd)
In vitro	WL47 TFA is a high-affinity caveolin-1 (CAV1) ligand (Kd=23 nM) that efficiently disrupts CAV1 oligomers. WL47 TFA exhibits higher selectivity for CAV1 compared to BSA, casein and HEWL. [1]
Synonyms	WL 47 TFA

Chemical Properties

Molecular Weight	1814.16
Formula	C₇₆H₁₁₉F₃N₂₂O₁₈S₄
Smiles	[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@H](C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CCSC)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)=O)=O)CO)=O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCCN.O=C(O)C(F)(F)F
Sequence	Lys-Leu-Arg-Met-Trp-Ser-Cys-Cys-Ser-Trp-Met-Arg-Leu-Lys
Sequence Short	KLRMWSCCSWMRLK

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (22.05 mM), Sonication is recommended.

H2O: 20 mg/mL (11.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.5512 mL	2.7561 mL	5.5122 mL	27.5610 mL
5 mM	0.1102 mL	0.5512 mL	1.1024 mL	5.5122 mL
10 mM	0.0551 mL	0.2756 mL	0.5512 mL	2.7561 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0276 mL	0.1378 mL	0.2756 mL	1.3780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc