CLEC2D Protein, Mouse, Recombinant (His)

Name: CLEC2D Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01252
Rating: 4.5 (1 reviews)

(Synonyms: Osteoclast inhibitory lectin, Ocil, Lectin-like transmembrane protein, C-type lectin-related protein B, C-type lectin domain family 2 member D, Clr-b, Clrb, Clec2d) Copy Product Info

Synonyms: Osteoclast inhibitory lectin, Ocil, Lectin-like transmembrane protein, C-type lectin-related protein B, C-type lectin domain family 2 member D, Clr-b, Clrb, Clec2d

Catalog No. TMPJ-01252 Copy Product Info

C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tumor cells can show reduced global levels of histone modification, which may favor Clec2d sensing. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.

CLEC2D Protein, Mouse, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
5 µg	$55	7-10 days	7-10 days
10 µg	$86	7-10 days	7-10 days
20 µg	$137	7-10 days	7-10 days
50 µg	$262	7-10 days	7-10 days
100 µg	$496	7-10 days	7-10 days
200 µg	$989	7-10 days	7-10 days
500 µg	$2,420	7-10 days	7-10 days
1 mg	$3,630	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tumor cells can show reduced global levels of histone modification, which may favor Clec2d sensing. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.
Species	Mouse
Expression System	HEK293 Cells
Tag	N-6xHis
Accession Number	Q91V08
Amino Acid	Leu63-Ser207
Construction	Leu63-Ser207
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Osteoclast inhibitory lectin, Ocil, Lectin-like transmembrane protein, C-type lectin-related protein B, C-type lectin domain family 2 member D, Clr-b, Clrb, Clec2d
Research Background	C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tumor cells can show reduced global levels of histone modification, which may favor Clec2d sensing. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.

Chemical Properties

Molecular Weight

24-32 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.