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SMIP004

🥰Excellent
Catalog No. T16901Cas No. 143360-00-3

SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.

SMIP004

SMIP004

🥰Excellent
Purity: 99.86%
Catalog No. T16901Cas No. 143360-00-3
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$82In StockIn Stock
2 mg$118In StockIn Stock
5 mg$183In StockIn Stock
10 mg$278In StockIn Stock
25 mg$463In StockIn Stock
50 mg$667In StockIn Stock
1 mL x 10 mM (in DMSO)$136In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.86%
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Product Introduction

Bioactivity
Description
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
In vitro
SMIP004 reduces the levels of positive cell cycle regulators upregulates cyclin-dependent kinase inhibitors. It also causes G1 arrest, inhibition of colony formation in soft agar, and cell death [2].
In vivo
In SCID mice, SMIP004 effectively inhibits the growth of prostate and breast cancer xenografts [2].
Chemical Properties
Molecular Weight205.3
FormulaC13H19NO
Cas No.143360-00-3
SmilesCCCCC1=CC(C)=C(NC(C)=O)C=C1
Relative Density.1.003 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (487.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8709 mL24.3546 mL48.7092 mL243.5460 mL
5 mM0.9742 mL4.8709 mL9.7418 mL48.7092 mL
10 mM0.4871 mL2.4355 mL4.8709 mL24.3546 mL
20 mM0.2435 mL1.2177 mL2.4355 mL12.1773 mL
50 mM0.0974 mL0.4871 mL0.9742 mL4.8709 mL
100 mM0.0487 mL0.2435 mL0.4871 mL2.4355 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ubiquitin ligaseUbiquitin conjugating enzymeUbiquitin activating enzymeSMIP-004SMIP004SMIP 004SKP2 E3 ligaseInhibitorinhibitE3EnzymeE3 ligating enzymeE3 EnzymeE2EnzymeE2 EnzymeE2 conjugating enzymeE1EnzymeE1/E2/E3 EnzymeE1 EnzymeE1 activating enzymeApoptosis
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