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Anti-AMPK alpha 1 Polyclonal Antibody 2

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Catalog No. TMAB-00115
Alias wu:fa94c10, SNF1-like protein AMPK, Protein kinase AMP activated alpha 1 catalytic subunit, PRKAA1, PRKAA 1, MGC57364, MGC33776, kinase AMPK alpha1, im:7154392, hormone sensitive lipase kinase, HMG CoA reductase kinase, EC 2.7.11.1, cb116, C130083N04Rik, AMPKα1, AMPKα 1, AMPKalpha1, AMPKa1, AMPK-a, AMPK1, AMPK α1, AMPK α 1, AMPK alpha-1, AMPK alpha 1 chain, AMPK a1, AMPK 1, AMPK, AMP-activated protein kinase, catalytic, alpha-1, AMP-activate kinase alpha 1 subunit, AL024255, AI450832, AI194361, acetyl CoA carboxylase kinase, AAPK1, 5' AMP activated protein kinase catalytic subunit alpha 1, 5 AMP activated protein kinase catalytic alpha 1 chain, 5 AMP activated protein kinase alpha 1catalytic subunit

Anti-AMPK alpha 1 Polyclonal Antibody 2 is a Rabbit antibody targeting AMPK alpha 1. Anti-AMPK alpha 1 Polyclonal Antibody 2 can be used in ELISA.

Anti-AMPK alpha 1 Polyclonal Antibody 2

Anti-AMPK alpha 1 Polyclonal Antibody 2

😃Good
Catalog No. TMAB-00115Alias wu:fa94c10, SNF1-like protein AMPK, Protein kinase AMP activated alpha 1 catalytic subunit, PRKAA1, PRKAA 1, MGC57364, MGC33776, kinase AMPK alpha1, im:7154392, hormone sensitive lipase kinase, HMG CoA reductase kinase, EC 2.7.11.1, cb116, C130083N04Rik, AMPKα1, AMPKα 1, AMPKalpha1, AMPKa1, AMPK-a, AMPK1, AMPK α1, AMPK α 1, AMPK alpha-1, AMPK alpha 1 chain, AMPK a1, AMPK 1, AMPK, AMP-activated protein kinase, catalytic, alpha-1, AMP-activate kinase alpha 1 subunit, AL024255, AI450832, AI194361, acetyl CoA carboxylase kinase, AAPK1, 5' AMP activated protein kinase catalytic subunit alpha 1, 5 AMP activated protein kinase catalytic alpha 1 chain, 5 AMP activated protein kinase alpha 1catalytic subunit
Anti-AMPK alpha 1 Polyclonal Antibody 2 is a Rabbit antibody targeting AMPK alpha 1. Anti-AMPK alpha 1 Polyclonal Antibody 2 can be used in ELISA.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3727-10 days
200 μL$5287-10 days
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Product Introduction

Bioactivity
Description
Anti-AMPK alpha 1 Polyclonal Antibody 2 is a Rabbit antibody targeting AMPK alpha 1. Anti-AMPK alpha 1 Polyclonal Antibody 2 can be used in ELISA.
Synonymswu:fa94c10, SNF1-like protein AMPK, Protein kinase AMP activated alpha 1 catalytic subunit, PRKAA1, PRKAA 1, MGC57364, MGC33776, kinase AMPK alpha1, im:7154392, hormone sensitive lipase kinase, HMG CoA reductase kinase, EC 2.7.11.1, cb116, C130083N04Rik, AMPKα1, AMPKα 1, AMPKalpha1, AMPKa1, AMPK-a, AMPK1, AMPK α1, AMPK α 1, AMPK alpha-1, AMPK alpha 1 chain, AMPK a1, AMPK 1, AMPK, AMP-activated protein kinase, catalytic, alpha-1, AMP-activate kinase alpha 1 subunit, AL024255, AI450832, AI194361, acetyl CoA carboxylase kinase, AAPK1, 5' AMP activated protein kinase catalytic subunit alpha 1, 5 AMP activated protein kinase catalytic alpha 1 chain, 5 AMP activated protein kinase alpha 1catalytic subunit
Ig Type
IgG
Reactivity
(predicted:Human,Mouse,Rat,Cow,Rabbit,Sheep)
Application
Recommended Dose
ELISA: 1:5000-10000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters.
Tissue SpecificityLens as well as other tissues.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThe protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human AMPK alpha-1
Antigen Species
Human
Gene Name
PRKAA1
Gene ID
Protein Name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Biology Area
Integration of energy metabolism,Response to hypoxia,Metabolism,Integration of energy,Fatty acids,Hypoxia,Fatty acid oxidation,Cancer,Neurodegenerative disease,Amyloid,Other Kinases
Function
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
Chemical Properties
Molecular WeightTheoretical: 64 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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