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Anti-TREM-1 Antibody-PE (8K185)
🥰Excellent
Catalog No. TMAY-00920P
Anti-TREM-1 Antibody-PE (8K185) is a PE-conjugated Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody-PE (8K185) can be used in FCM.
Anti-TREM-1 Antibody-PE (8K185)
Anti-TREM-1 Antibody-PE (8K185)
🥰Excellent
Catalog No. TMAY-00920P
Anti-TREM-1 Antibody-PE (8K185) is a PE-conjugated Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody-PE (8K185) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TREM-1 Antibody-PE (8K185) is a PE-conjugated Mouse antibody targeting TREM-1. Anti-TREM-1 Antibody-PE (8K185) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8K185 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human TREM-1(CD354) expression on human whole blood granulocytes. Cells were stained with PE-conjugated anti-Human TREM-1(CD354). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TREM-1 / TREM1 (rh TREM-1 / TREM1; TMPY-00943; NP_061113.1; Met1-Arg200) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | TREM1 (triggering receptor expressed on myeloid cells) is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes. As a member of the growing family of receptors related to NK cell receptors, TREM1 activates downstream signaling events with the help of an adapter protein called DAP12. Expression of TREM1 is up-regulated by bacterial LPS, a ligand for TLR4, as well as lipoteichoic acid. Although its natural ligand has not been identified, engagement of TREM1 with agonist mAbs triggers secretion of the proinflammatory cytokines TNF-α and IL-1β, as well as chemokines such as IL-8 and monocyte chemoattractant protein (MCP)-1. Intracellularly, TREM1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-γ. In an animal model of LPS-induced septic shock, blockade of TREM1 signaling inhibited hyperresponsiveness and death. Thus, it has been demonstrated that TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock. |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human TREM-1 / TREM1 Protein (TMPY-00943) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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