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Olopatadine hydrochloride

Name: Olopatadine hydrochloride
Brand: TargetMol
SKU: T1170
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1170Cas No. 140462-76-6

Alias Olopatadine HCl, KW4679, ALO4943A

Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.

Olopatadine hydrochloride

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Purity: 99.64%

Catalog No. T1170Alias Olopatadine HCl, KW4679, ALO4943ACas No. 140462-76-6

Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$61	In Stock	In Stock
50 mg	$87	In Stock	In Stock
100 mg	$123	In Stock	In Stock
500 mg	$277	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Olopatadine hydrochloride AI Summary

Olopatadine hydrochloride exhibits diverse bioactivities across several biological systems. It shows inhibitory effects on passive cutaneous anaphylaxis in rats and IgG1-mediated bronchoconstriction in guinea pigs. Additionally, it has a binding affinity for the histamine H1 receptor and moderate inhibition of the Muscarinic acetylcholine receptor M1. In oncology, it induces DNA re-replication in SW480 colon adenocarcinoma cells at a potency of 1778.3 nM. For antiviral activity, it can block the entry of the Ebola virus with an AC50 of 44.67 µM, inhibit cell viability in Vero E6 cells infected with SARS-CoV-2, and demonstrated inhibition of cytotoxicity in Caco-2 cells exposed to SARS-CoV-2 at a 10 µM concentration with an inhibition of -1.88%. Furthermore, it minimally inhibits the SARS-CoV-2 3CL-Pro protease with -2.774% inhibition at 20 µM. Olopatadine hydrochloride also shows notable antifungal activity against Candida albicans and Cryptococcus neoformans, with inhibition rates of 4.03% and 4.6%, respectively. Its antibacterial effects include activity against Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii, although it shows no inhibition against Pseudomonas aeruginosa and Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.
Synonyms	Olopatadine HCl, KW4679, ALO4943A

Chemical Properties

Molecular Weight	373.87
Formula	C₂₁H₂₃NO₃·HCl
Cas No.	140462-76-6
Smiles	c12/C(=C\CCN(C)C)/c3c(COc1ccc(c2)CC(=O)O)cccc3.Cl
Relative Density.	1.221 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (147.11 mM), Sonication is recommended.

H2O: 28 mg/mL (74.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6747 mL	13.3736 mL	26.7473 mL	133.7363 mL
5 mM	0.5349 mL	2.6747 mL	5.3495 mL	26.7473 mL
10 mM	0.2675 mL	1.3374 mL	2.6747 mL	13.3736 mL
20 mM	0.1337 mL	0.6687 mL	1.3374 mL	6.6868 mL
50 mM	0.0535 mL	0.2675 mL	0.5349 mL	2.6747 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0267 mL	0.1337 mL	0.2675 mL	1.3374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc