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NC-III-49-1

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Catalog No. T74898Cas No. 3031654-46-0

NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].

NC-III-49-1

NC-III-49-1

😃Good
Catalog No. T74898Cas No. 3031654-46-0
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$3556-8 weeks6-8 weeks
5 mg$8536-8 weeks6-8 weeks
10 mg$1,1806-8 weeks6-8 weeks
25 mg$1,7506-8 weeks6-8 weeks
50 mg$2,3606-8 weeks6-8 weeks
100 mg$3,1906-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].
Targets&IC50
BRD41:0.095 nM (Kd), BRD4(2):0.032 nM (Kd), BRD4-T:0.29 nM (Kd), BRDT-T:0.058 nM (Kd), BRDT (1):0.089 nM (Kd), BRDT2:5.5 nM (Kd)
Chemical Properties
Molecular Weight875.02
FormulaC44H50N4O11S2
Cas No.3031654-46-0
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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