Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential against COVID-19 by modulating SARS-CoV-2 interactors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 427.00 | |
50 mg | In stock | Inquiry |
Description | TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential against COVID-19 by modulating SARS-CoV-2 interactors. |
Targets&IC50 | TPase:47 nM (IC50) |
In vitro | TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%). TH1217 presents suitable mouse microsomal half-lives (109 minutes). TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition[1]. |
Synonyms | TH 1217 |
Molecular Weight | 491.09 |
Formula | C20H17BCl2N4O6 |
CAS No. | 1862212-48-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 117 mg/mL (238.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TH1217 1862212-48-3 Others TH-1217 TH 1217 inhibitor inhibit