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TH1217

Name: TH1217
Brand: TargetMol
SKU: T38271
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38271Cas No. 1862212-48-3

Alias TH 1217

TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential against COVID-19 by modulating SARS-CoV-2 interactors.

TH1217

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Purity: 99.3%

Catalog No. T38271Alias TH 1217Cas No. 1862212-48-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
2 mg	$50	-	In Stock
5 mg	$81	-	In Stock
10 mg	$129	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$99	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.3%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential against COVID-19 by modulating SARS-CoV-2 interactors.
Targets&IC50	TPase:47 nM (IC50)
In vitro	TH1217 (compound 30) inhibits dCTPase, enhances aqueous solubility (>100 μM), and improves plasma stability in vitro (t4h=86%), with suitable mouse microsomal half-lives (109 minutes). TH1217 displays good cell permeability (8.66×10^-6/1.30×10^-3 cm/s) and CYP inhibition[1].
Synonyms	TH 1217

Chemical Properties

Molecular Weight	491.09
Formula	C₂₀H₁₇BCl₂N₄O₆
Cas No.	1862212-48-3
Smiles	Cc1nc2c(c(Cl)c(Cl)cc2n1Cc1ccc(cc1)[B-]12OC(=O)C[N+]1(C)CC(=O)O2)[N+]([O-])=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 117 mg/mL (238.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0363 mL	10.1814 mL	20.3629 mL	101.8143 mL
5 mM	0.4073 mL	2.0363 mL	4.0726 mL	20.3629 mL
10 mM	0.2036 mL	1.0181 mL	2.0363 mL	10.1814 mL
20 mM	0.1018 mL	0.5091 mL	1.0181 mL	5.0907 mL
50 mM	0.0407 mL	0.2036 mL	0.4073 mL	2.0363 mL
100 mM	0.0204 mL	0.1018 mL	0.2036 mL	1.0181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc