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Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2

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Catalog No. T38971Cas No. 148579-93-5
Alias Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable linker used in ADC synthesis for conjugation with antibodies, ultimately yielding antibody-drug conjugates (ADCs).

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2

😃Good
Catalog No. T38971Alias Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2Cas No. 148579-93-5
Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable linker used in ADC synthesis for conjugation with antibodies, ultimately yielding antibody-drug conjugates (ADCs).
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Product Introduction

Bioactivity
Description
Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable linker used in ADC synthesis for conjugation with antibodies, ultimately yielding antibody-drug conjugates (ADCs).
In vitro
ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker.
SynonymsMe-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2
Chemical Properties
Molecular Weight483.382
FormulaC20H21NO13
Cas No.148579-93-5
SmilesCOC(=O)[C@H]1O[C@@H](Oc2ccc(C=O)cc2N(=O)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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