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K34c hydrochloride (Alias: K34c hydrochloride(939769-93-4 Free base))

Name: K34c hydrochloride
Brand: TargetMol
SKU: T41151L
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T41151L Copy Product Info

Purity: 99.89%

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K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.

K34c hydrochloride

Copy Product Info

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Catalog No. T41151L

Alias K34c hydrochloride(939769-93-4 Free base)

K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.

Cas No. 2986315-25-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$210	In Stock	In Stock
5 mg	$497	In Stock	In Stock
10 mg	$678	In Stock	In Stock
25 mg	$953	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$560	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.89%

ee:97.21%

Appearance:Solid

Color:White

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COA HNMR LCMS CSFC IC

Product Introduction

Bioactivity

Description	K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
In vitro	K34c (20 μM; 24 or 48 h) in combination with 1 μM Ellipticine induces significant apoptosis in U87MG cells.[1] K34c (20 μM; 48 h) significantly decreases Temozolomide-induced senescence in cells transfected with control nontargeting siRNA, without significantly affecting the residual.[1] K34c (20 μM; 24 h) alters the p53 pathway and senescence of cells transfected with siRNA specific for p53.[1]
Synonyms	K34c hydrochloride(939769-93-4 Free base)

Chemical Properties

Molecular Weight	483.99
Formula	C₂₆H₃₀ClN₃O₄
Cas No.	2986315-25-5
Smiles	O=C(C1=C(C=CC=C1C)C)N[C@H](C(O)=O)CC2=CC=C(C=C2)OCCCNC3=CC=CC=N3.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (56.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0662 mL	10.3308 mL	20.6616 mL	103.3079 mL
5 mM	0.4132 mL	2.0662 mL	4.1323 mL	20.6616 mL
10 mM	0.2066 mL	1.0331 mL	2.0662 mL	10.3308 mL
20 mM	0.1033 mL	0.5165 mL	1.0331 mL	5.1654 mL
50 mM	0.0413 mL	0.2066 mL	0.4132 mL	2.0662 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc