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Anti-ARMET/MANF Antibody (1O944)
😃Good
Catalog No. TMAY-03497
Alias mesencephalic astrocyte-derived neurotrophic factor, D18Mgi17, D17914, Armet, AA673178, AA408789, AA407711, 3230402M22Rik
Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA.
Anti-ARMET/MANF Antibody (1O944)
Anti-ARMET/MANF Antibody (1O944)
😃Good
Catalog No. TMAY-03497Alias mesencephalic astrocyte-derived neurotrophic factor, D18Mgi17, D17914, Armet, AA673178, AA408789, AA407711, 3230402M22Rik
Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA. |
| Alias | mesencephalic astrocyte-derived neurotrophic factor, D18Mgi17, D17914, Armet, AA673178, AA408789, AA407711, 3230402M22Rik |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 1O944 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MANF (TMPY-02732; NP_083379.2; Met1-Leu179). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral midbrain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus, and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggests that it has important functions both under normal and pathological conditions in many tissue types. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse MANF protein (TMPY-02732) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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