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Anti-ARMET/MANF Antibody (1O944) (Synonyms: mesencephalic astrocyte-derived neurotrophic factor, D18Mgi17, D17...)
Catalog No. TMAY-03497 Copy Product Info
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Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA.
Anti-ARMET/MANF Antibody (1O944)
Copy Product Info🥰Excellent
Catalog No. TMAY-03497
Synonyms mesencephalic astrocyte-derived neurotrophic factor, D18Mgi17, D17914, Armet, AA673178, AA408789, AA407711, 3230402M22Rik
Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA.
Anti-ARMET/MANF Antibody
(1O944)
(1O944)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $268 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-ARMET/MANF Antibody (1O944) is a Rabbit antibody targeting ARMET/MANF. Anti-ARMET/MANF Antibody (1O944) can be used in ELISA. |
| Synonyms | mesencephalic astrocyte-derived neurotrophic factor, D18Mgi17, D17914, Armet, AA673178, AA408789, AA407711, 3230402M22Rik |
| Ig Type | Rabbit IgG |
| Clone | 1O944 |
| Reactivity | Mouse |
| Specificity | Mouse MANF Has cross-reactivity in ELISA with Human MANF |
| Application | |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MANF (TMPY-02732; NP_083379.2; Met1-Leu179). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of dopaminergic neurons of the ventral midbrain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. ARMET enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. ARMET inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus, and cerebellar Purkinje cells. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggests that it has important functions both under normal and pathological conditions in many tissue types. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse MANF protein (TMPY-02732) |
| Antigen Species | Mouse |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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