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UZH1a

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Catalog No. T37448Cas No. 2813577-78-3

UZH1a is a potent and selective inhibitor of METTL3, with an IC50 of 280 nM. It serves as a tool for the epitranscriptomic modulation of cellular processes, exhibits antitumor activity, and functions as a chemical probe for the study of METTL3[1].

UZH1a

UZH1a

😃Good
Catalog No. T37448Cas No. 2813577-78-3
UZH1a is a potent and selective inhibitor of METTL3, with an IC50 of 280 nM. It serves as a tool for the epitranscriptomic modulation of cellular processes, exhibits antitumor activity, and functions as a chemical probe for the study of METTL3[1].
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5 mg$946InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
UZH1a is a potent and selective inhibitor of METTL3, with an IC50 of 280 nM. It serves as a tool for the epitranscriptomic modulation of cellular processes, exhibits antitumor activity, and functions as a chemical probe for the study of METTL3[1].
In vitro
UZH1a (2.5-160 μM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 μM, 67 μM, and 87 μM, respectively[1].UZH1a (2.5-100 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13 cells in a dose-dependent manner (IC50=4.6 μM)[1].UZH1a (40 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells[1].UZH1a (20 μM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells[1].
Chemical Properties
Molecular Weight558.71
FormulaC32H42N6O3
Cas No.2813577-78-3
Relative Density.1.234 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (143.19 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (8.95 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7898 mL8.9492 mL17.8984 mL89.4919 mL
5 mM0.3580 mL1.7898 mL3.5797 mL17.8984 mL
10 mM0.1790 mL0.8949 mL1.7898 mL8.9492 mL
20 mM0.0895 mL0.4475 mL0.8949 mL4.4746 mL
50 mM0.0358 mL0.1790 mL0.3580 mL1.7898 mL
100 mM0.0179 mL0.0895 mL0.1790 mL0.8949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

UZH-1aUZH1a
Related Tags: buy UZH1a | purchase UZH1a | UZH1a cost | order UZH1a | UZH1a chemical structure | UZH1a in vitro | UZH1a formula | UZH1a molecular weight
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