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Solamargine

Name: Solamargine
Brand: TargetMol
SKU: T4034
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4034Cas No. 20311-51-7

Alias δ-Solanigrine, Solamargin

Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.

Solamargine

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Purity: 99.96%

Catalog No. T4034Alias δ-Solanigrine, SolamarginCas No. 20311-51-7

Pack Size	Price	Availability
1 mg	$54	In Stock
5 mg	$117	In Stock
10 mg	$177	In Stock
25 mg	$363	In Stock
50 mg	$562	In Stock
100 mg	$790	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock

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Purity:99.96%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
In vitro	Solamargine concentration-dependently reduced HepG2 cell viability. Solamargine (7.5 μM) reduced cell viability by less than 20% in HepG2 cells. Solamargine (highest dose) decreased cell invasion and migration by more than 72% and 70% in HepG2 cells, respectively. Solamargine reduced function and expression of MMP-2/9 proteins. Solamargine time-dependently increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a fashion.
Synonyms	δ-Solanigrine, Solamargin

Chemical Properties

Molecular Weight	868.06
Formula	C₄₅H₇₃NO₁₅
Cas No.	20311-51-7
Smiles	C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@H](O)[C@H]2O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)O[C@]11CC[C@@H](C)CN1
Relative Density.	1.38 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (104.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1520 mL	5.7600 mL	11.5199 mL	57.5997 mL
5 mM	0.2304 mL	1.1520 mL	2.3040 mL	11.5199 mL
10 mM	0.1152 mL	0.5760 mL	1.1520 mL	5.7600 mL
20 mM	0.0576 mL	0.2880 mL	0.5760 mL	2.8800 mL
50 mM	0.0230 mL	0.1152 mL	0.2304 mL	1.1520 mL
100 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.5760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc