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Succinyl phosphonate

Name: Succinyl phosphonate
Brand: TargetMol
SKU: T13020
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13020Cas No. 26647-82-5

Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC ) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation. Succinyl phosphonate trisodium salt inhibits glutamate-induced ROS generation in glutamate-stimulated hippocampal neurons and can be used to study neurodegenerative diseases.

Succinyl phosphonate

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Catalog No. T13020Cas No. 26647-82-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$293	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description

In vitro

Succinyl phosphonate (0.01 mM) completely inhibits isolated brain KGDHC even in the presence of a 200-fold higher concentration of its substrate. In cultured human fibroblasts, 0.01 mM Succinyl phosphonate produced 70% inhibition of α-ketoglutarate dehydrogenase complex. [2]
Succinyl phosphonate inhibits 2-Oxoglutarate dehydrogenase, the first rate-limiting component of the mitochondrial multi-enzyme complex of oxidative decarboxylation of 2-oxoglutarate, in a highly selective and efficient manner. [3]

Chemical Properties

Molecular Weight	182.07
Formula	C₄H₇O₆P
Cas No.	26647-82-5
Smiles	O=C(O)CCC(=O)P(=O)(O)O
Relative Density.	1.726 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 30 mg/mL (164.77 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4924 mL	27.4620 mL	54.9239 mL	274.6197 mL
5 mM	1.0985 mL	5.4924 mL	10.9848 mL	54.9239 mL
10 mM	0.5492 mL	2.7462 mL	5.4924 mL	27.4620 mL
20 mM	0.2746 mL	1.3731 mL	2.7462 mL	13.7310 mL
50 mM	0.1098 mL	0.5492 mL	1.0985 mL	5.4924 mL
100 mM	0.0549 mL	0.2746 mL	0.5492 mL	2.7462 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc