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IL-22BP Protein, Human, Recombinant (Isoform 2, His)
(Synonyms: ZCYTOR16, interleukin 22 receptor, α2, interleukin 22 receptor, alpha 2, IL-22R-α-2, IL-22R-alpha-2, IL-22RA2, IL-22BP, CRF2X, CRF2-S1, CRF2-10) Copy Product InfoSynonyms: ZCYTOR16, interleukin 22 receptor, α2, interleukin 22 receptor, alpha 2, IL-22R-α-2, IL-22R-alpha-2, IL-22RA2, IL-22BP, CRF2X, CRF2-S1, CRF2-10
Catalog No. TMPY-01220 Copy Product Info
IL-22BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is Q969J5-2.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $93 | 7-10 days | 7-10 days | |
| 10 µg | $152 | 7-10 days | 7-10 days | |
| 20 µg | $248 | 7-10 days | 7-10 days | |
| 50 µg | $498 | 7-10 days | 7-10 days | |
| 100 µg | $833 | 7-10 days | 7-10 days | |
| 200 µg | $1,370 | 7-10 days | 7-10 days | |
| 500 µg | $2,730 | 7-10 days | 7-10 days | |
| 1 mg | $5,300 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 , The EC50 of biotinylated IL22 is 1.78-4.14 ng/ml. |
| Description | IL-22BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is Q969J5-2. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q969J5-2 |
| Construction | A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed, fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Thr 22 |
| Protein Purity | > 95 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | ZCYTOR16, interleukin 22 receptor, α2, interleukin 22 receptor, alpha 2, IL-22R-α-2, IL-22R-alpha-2, IL-22RA2, IL-22BP, CRF2X, CRF2-S1, CRF2-10 |
| Research Background | Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type II cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in the placenta, spleen, breast, skin, and lung. It is also detected in the intestinal tract, testis, brain, heart, and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of the IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important role in the immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptors have been discovered, a membrane-bound receptor and a soluble receptor. |
| Molecular Weight | 26.1 kDa (predicted); 50-55 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-22BP Protein, Human, Recombinant (Isoform 2, His) chemical structure | IL-22BP Protein, Human, Recombinant (Isoform 2, His) molecular weight
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