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Trilaciclib

🥰Excellent
Catalog No. T13202LCas No. 1374743-00-6

Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. It transiently and reversibly induces G1 cell cycle arrest, mitigates chemotherapy-induced myelosuppression, and enhances antitumour immunity, making it applicable across multiple cancers.

Trilaciclib

Trilaciclib

🥰Excellent
Purity: 99.624%
Catalog No. T13202LCas No. 1374743-00-6
Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. It transiently and reversibly induces G1 cell cycle arrest, mitigates chemotherapy-induced myelosuppression, and enhances antitumour immunity, making it applicable across multiple cancers.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$89In Stock
10 mg$163In Stock
25 mg$328In Stock
50 mg$579In Stock
100 mg$786In Stock
200 mg$1,080In Stock
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Purity:99.624%
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Product Introduction

Bioactivity
Description
Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. It transiently and reversibly induces G1 cell cycle arrest, mitigates chemotherapy-induced myelosuppression, and enhances antitumour immunity, making it applicable across multiple cancers.
Targets&IC50
CDK6:4 nM, CDK4:1 nM
In vitro
Methods: HS68 cells were treated with Trilaciclib (10-3000nM, 24 hours), fixed and stained with propidium iodide and RNAse A, then analyzed using a Cyan ADP Analyzer.
Results: After 24 hours of treatment with 300 nM trilaciclib, the proportion of HS68 cells in the G1 phase reached as high as 98%.[1]
In vivo
Method: FVB/N mice were orally administered Trilaciclib (50, 100, 150 mg/kg, single dose), followed by EdU injection to measure the proliferation of bone marrow Lineage-negative cells.
Results: Trilaciclib exhibited a dose-dependent effect, effectively suppressing the proliferation of bone marrow HSPCs. [1]
Chemical Properties
Molecular Weight446.55
FormulaC24H30N8O
Cas No.1374743-00-6
SmilesCN1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Relative Density.1.46 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.5 mg/mL (10.08 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2394 mL11.1970 mL22.3939 mL111.9695 mL
5 mM0.4479 mL2.2394 mL4.4788 mL22.3939 mL
10 mM0.2239 mL1.1197 mL2.2394 mL11.1970 mL

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