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Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. It transiently and reversibly induces G1 cell cycle arrest, mitigates chemotherapy-induced myelosuppression, and enhances antitumour immunity, making it applicable across multiple cancers.

| Pack Size | Price | Availability | Quantity | 
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $328 | In Stock | |
| 50 mg | $579 | In Stock | |
| 100 mg | $786 | In Stock | |
| 200 mg | $1,080 | In Stock | 
| Description | Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. It transiently and reversibly induces G1 cell cycle arrest, mitigates chemotherapy-induced myelosuppression, and enhances antitumour immunity, making it applicable across multiple cancers. | 
| Targets&IC50 |  CDK6:4 nM, CDK4:1 nM | 
| In vitro | Methods: HS68 cells were treated with Trilaciclib (10-3000nM, 24 hours), fixed and stained with propidium iodide and RNAse A, then analyzed using a Cyan ADP Analyzer.  Results: After 24 hours of treatment with 300 nM trilaciclib, the proportion of HS68 cells in the G1 phase reached as high as 98%.[1] | 
| In vivo | Method: FVB/N mice were orally administered Trilaciclib (50, 100, 150 mg/kg, single dose), followed by EdU injection to measure the proliferation of bone marrow Lineage-negative cells.  Results: Trilaciclib exhibited a dose-dependent effect, effectively suppressing the proliferation of bone marrow HSPCs. [1] | 
| Molecular Weight | 446.55 | 
| Formula | C24H30N8O | 
| Cas No. | 1374743-00-6 | 
| Smiles | CN1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1 | 
| Relative Density. | 1.46 g/cm3 (Predicted) | 
| Color | Yellow | 
| Appearance | Solid | 
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (10.08 mM)  | ||||||||||||||||||||
| Solution Preparation Table | |||||||||||||||||||||
| DMSO 
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 For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL .
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL .  A total of 10 animals were administered, and the formula you used is 5%
 A total of 10 animals were administered, and the formula you used is 5%  DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。 (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
 (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first. main solution, add 300 μLPEG300
 main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O
 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
 mix well and clarify
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