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Anti-APAF1(NT) Polyclonal Antibody
(Synonyms: KIAA0413, CED4, CED 4, Apoptotic protease-activating factor 1, Apoptotic protease activating factor, Apoptotic peptidase activating factor 1, APAF1, APAF 1, APAF) Copy Product Info
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Synonyms: KIAA0413, CED4, CED 4, Apoptotic protease-activating factor 1, Apoptotic protease activating factor, Apoptotic peptidase activating factor 1, APAF1, APAF 1, APAF
Catalog No. TMAB-00126 Copy Product Info
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Anti-APAF1(NT) Polyclonal Antibody is a Rabbit antibody targeting APAF1(NT). Anti-APAF1(NT) Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-APAF1
(NT) Polyclonal Antibody
(NT) Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-APAF1(NT) Polyclonal Antibody is a Rabbit antibody targeting APAF1(NT). Anti-APAF1(NT) Polyclonal Antibody can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | KIAA0413, CED4, CED 4, Apoptotic protease-activating factor 1, Apoptotic protease activating factor, Apoptotic peptidase activating factor 1, APAF1, APAF 1, APAF |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Cow,Horse) |
| Application | |
| Recommended Dose | FCM=0.2 μg/Test; ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain(NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human Apaf-1 |
| Antigen Species | Human |
| Gene Name | APAF1 |
| Gene ID | |
| Protein Name | Apoptotic protease-activating factor 1 |
| Uniprot ID | |
| Biology Area | Cytochrome C,Metabolism,Mitochondrial,Cytochrome C,Mitochondrial,Apoptosis,Mitochondrial markers |
| Function | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. |
| Molecular Weight | Theoretical: 137 kDa. Actual: 140 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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