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Azido-PEG7-amine

🥰Excellent
Catalog No. T14475Cas No. 1333154-77-0

Azido-PEG7-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.

Azido-PEG7-amine

Azido-PEG7-amine

🥰Excellent
Purity: 97.39%
Catalog No. T14475Cas No. 1333154-77-0
Azido-PEG7-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.
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10 mg$32In Stock
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Purity:97.39%
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Product Introduction

Bioactivity
Description
Azido-PEG7-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.
Chemical Properties
Molecular Weight394.46
FormulaC16H34N4O7
Cas No.1333154-77-0
Smiles[N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCN
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 80 mg/mL (202.81 mM), Sonication is recommended.
DMSO: 80 mg/mL (202.81 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.5351 mL12.6756 mL25.3511 mL126.7556 mL
5 mM0.5070 mL2.5351 mL5.0702 mL25.3511 mL
10 mM0.2535 mL1.2676 mL2.5351 mL12.6756 mL
20 mM0.1268 mL0.6338 mL1.2676 mL6.3378 mL
50 mM0.0507 mL0.2535 mL0.5070 mL2.5351 mL
100 mM0.0254 mL0.1268 mL0.2535 mL1.2676 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Non-cleavableAzido-PEG7-amineAzido-PEG-7-amineAzidoPEG7amineAzido PEG7 amineADCLinkerADC Linker
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