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CCR6 inhibitor 1
🥰Excellent
Catalog No. T10715Cas No. 2437547-04-9
CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor 1 is useful for in vitro and in vivo pathophysiology studies as a small molecule inhibitor of CCR6.
CCR6 inhibitor 1
🥰Excellent
Purity: 99.89%
Catalog No. T10715Cas No. 2437547-04-9
CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor 1 is useful for in vitro and in vivo pathophysiology studies as a small molecule inhibitor of CCR6.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $118 | In Stock | |
| 5 mg | $297 | In Stock | |
| 10 mg | $446 | In Stock | |
| 25 mg | $717 | In Stock | |
| 50 mg | $983 | In Stock | |
| 100 mg | $1,370 | In Stock | |
| 500 mg | $2,750 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $328 | In Stock |
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Purity:99.89%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor 1 is useful for in vitro and in vivo pathophysiology studies as a small molecule inhibitor of CCR6. |
| Targets&IC50 | CCR6 (human):6 nM, CCR7 (human):9400 nM, CCR6 (monkey):0.45 nM |
| In vitro | CCR6 inhibitor 1 in human CCR6-transfected CHO cells showed a good correlation between Gi signal inhibitory activity and cell migration inhibitory activity, which could effectively inhibit CCR6-dependent cell migration and ERK phosphorylation increase in human primary cells[1]. |
| Molecular Weight | 504.52 |
| Formula | C24H23F3N4O3S |
| Cas No. | 2437547-04-9 |
| Smiles | NC(=O)c1cc(ccn1)-c1ccc(cc1)S(=O)(=O)[C@H]1CC[C@@H](CC1)Nc1ccc(cn1)C(F)(F)F |
| Relative Density. | 1.391 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 112.5 mg/mL (222.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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